An Unusual Location of Deep Venous Thrombosis Associated with Ischemic Stroke and Persistent Foramen Ovale
Up to 40% of ischemic strokes have no known cause (cryptogenic). The prevalence of persistent foramen ovale (PFO) amongst patients with cryptogenic stroke (CS) is twice as high as that of the normal population, therefore suggesting a causal relationship between the two entities. However, PFO by itse...
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doaj-fb155b46a0a14c6da48e6336904ce60e2020-11-24T21:06:32ZengKarger PublishersCase Reports in Neurology1662-680X2011-07-013216016410.1159/000330376330376An Unusual Location of Deep Venous Thrombosis Associated with Ischemic Stroke and Persistent Foramen OvaleJ. ErharhaghenM. BartzS. Di GiovanniA. MelmsT. HaarmeierL. SieverdingUp to 40% of ischemic strokes have no known cause (cryptogenic). The prevalence of persistent foramen ovale (PFO) amongst patients with cryptogenic stroke (CS) is twice as high as that of the normal population, therefore suggesting a causal relationship between the two entities. However, PFO by itself is not sufficient to cause stroke, as an embolic source is needed. This source is often unknown, making the causal relationship between CS and PFO hard to demonstrate. The most frequent, although still seldom, identifiable cause of embolism in an otherwise cryptogenic stroke associated with PFO is a deep venous thrombosis (DVT) of the lower extremities. Here, we present a unique case of brachiocephalic venous DVT associated with PFO and ischemic stroke in a young patient. As the search for DVT in patients with PFO and stroke is often limited to the lower extremities, this case may suggest that an unspecified number of DVTs are overlooked. Our report lends support to paradoxical embolism as a mechanism of stroke in patients with PFO and does, at least in selected cases, suggest a more detailed search for DVT beyond the lower extremities.http://www.karger.com/Article/FullText/330376Ischemic strokeCryptogenic strokePersistent foramen ovaleDeep venous thrombosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
J. Erharhaghen M. Bartz S. Di Giovanni A. Melms T. Haarmeier L. Sieverding |
spellingShingle |
J. Erharhaghen M. Bartz S. Di Giovanni A. Melms T. Haarmeier L. Sieverding An Unusual Location of Deep Venous Thrombosis Associated with Ischemic Stroke and Persistent Foramen Ovale Case Reports in Neurology Ischemic stroke Cryptogenic stroke Persistent foramen ovale Deep venous thrombosis |
author_facet |
J. Erharhaghen M. Bartz S. Di Giovanni A. Melms T. Haarmeier L. Sieverding |
author_sort |
J. Erharhaghen |
title |
An Unusual Location of Deep Venous Thrombosis Associated with Ischemic Stroke and Persistent Foramen Ovale |
title_short |
An Unusual Location of Deep Venous Thrombosis Associated with Ischemic Stroke and Persistent Foramen Ovale |
title_full |
An Unusual Location of Deep Venous Thrombosis Associated with Ischemic Stroke and Persistent Foramen Ovale |
title_fullStr |
An Unusual Location of Deep Venous Thrombosis Associated with Ischemic Stroke and Persistent Foramen Ovale |
title_full_unstemmed |
An Unusual Location of Deep Venous Thrombosis Associated with Ischemic Stroke and Persistent Foramen Ovale |
title_sort |
unusual location of deep venous thrombosis associated with ischemic stroke and persistent foramen ovale |
publisher |
Karger Publishers |
series |
Case Reports in Neurology |
issn |
1662-680X |
publishDate |
2011-07-01 |
description |
Up to 40% of ischemic strokes have no known cause (cryptogenic). The prevalence of persistent foramen ovale (PFO) amongst patients with cryptogenic stroke (CS) is twice as high as that of the normal population, therefore suggesting a causal relationship between the two entities. However, PFO by itself is not sufficient to cause stroke, as an embolic source is needed. This source is often unknown, making the causal relationship between CS and PFO hard to demonstrate. The most frequent, although still seldom, identifiable cause of embolism in an otherwise cryptogenic stroke associated with PFO is a deep venous thrombosis (DVT) of the lower extremities. Here, we present a unique case of brachiocephalic venous DVT associated with PFO and ischemic stroke in a young patient. As the search for DVT in patients with PFO and stroke is often limited to the lower extremities, this case may suggest that an unspecified number of DVTs are overlooked. Our report lends support to paradoxical embolism as a mechanism of stroke in patients with PFO and does, at least in selected cases, suggest a more detailed search for DVT beyond the lower extremities. |
topic |
Ischemic stroke Cryptogenic stroke Persistent foramen ovale Deep venous thrombosis |
url |
http://www.karger.com/Article/FullText/330376 |
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