Dynamic Neuromagnetic Network Changes of Seizure Termination in Absence Epilepsy: A Magnetoencephalography Study

• Main Authors: Wenwen Jiang, Caiyun Wu, Jing Xiang, Ailiang Miao, Wenchao Qiu, Lu Tang, Shuyang Huang, Qiqi Chen, Zheng Hu, Xiaoshan Wang
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2019-07-01
• Series: Frontiers in Neurology
• Subjects: childhood absence epilepsy; magnetoencephalography; source localization; effective connectivity; cortico–thalamic network; seizure termination
• Online Access: https://www.frontiersin.org/article/10.3389/fneur.2019.00703/full

Objective: With increasing efforts devoted to investigating the generation and propagation mechanisms of spontaneous spike and wave discharges (SWDs), little attention has been paid to network mechanisms associated with termination patterns of SWDs to date. In the current study, we aimed to identify the frequency-dependent neural network dynamics during the offset of absence seizures.Methods: Fifteen drug-naïve patients with childhood absence epilepsy (CAE) were assessed with a 275-Channel Magnetoencephalography (MEG) system. MEG data were recorded during and between seizures at a sampling rate of 6,000 Hz and analyzed in seven frequency bands. Source localization was performed with accumulated source imaging. Granger causality analysis was used to evaluate effective connectivity networks of the entire brain at the source level.Results: At the low-frequency (1–80 Hz) bands, activities were predominantly distributed in the frontal cortical and parieto–occipito–temporal junction at the offset transition periods. The high-frequency oscillations (HFOs, 80–500 Hz) analysis indicated significant source localization in the medial frontal cortex and deep brain areas (mainly thalamus) during both the termination transition and interictal periods. Furthermore, an enhanced positive cortico–thalamic effective connectivity was observed around the discharge offset at all of the seven analyzed bands, the direction of which was primarily from various cortical regions to the thalamus.Conclusions: Seizure termination is a gradual process that involves both the cortices and the thalamus in CAE. Cortico–thalamic coupling is observed at the termination transition periods, and the cerebral cortex acts as the driving force.