Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses

Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses

Amino acids (AAs) are necessary nutrients which act not only as building blocks in protein synthesis but also in crucial anabolic cellular signaling pathways. It has been demonstrated that SLC7A5 is a critical transporter that mediates uptake of several essential amino acids in highly proliferative...

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Bibliographic Details
Main Authors: Bo Ruem Yoon, Yoon-Jeong Oh, Seong Wook Kang, Eun Bong Lee, Won-Woo Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
monocyte
macrophage
leucine
mTOR complex 1
glycolysis
rheumatoid arthritis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00053/full

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