Associations between the measures of physical function, risk of falls and the quality of life in haemodialysis patients: a cross-sectional study
Abstract Background Impaired physical function due to muscle weakness and exercise intolerance reduces the ability to perform activities of daily living in patients with end-stage kidney disease, and by consequence, Health-Related Quality of Life (HRQoL). Furthermore, the risk of falls is an aggrega...
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doaj-fb3a37f64394447c95b6b29fa2884ef72021-01-10T12:58:25ZengBMCBMC Nephrology1471-23692020-01-0121111010.1186/s12882-019-1671-9Associations between the measures of physical function, risk of falls and the quality of life in haemodialysis patients: a cross-sectional studyKarsten Vanden Wyngaert0Amaryllis H. Van Craenenbroeck1Sunny Eloot2Patrick Calders3Bert Celie4Els Holvoet5Wim Van Biesen6Department of Rehabilitation Sciences, Faculty of Medicine and Health Sciences, Ghent UniversityDepartment of Nephrology, University Hospitals LeuvenDepartment of Internal Medicine, Renal Division, Ghent University HospitalDepartment of Rehabilitation Sciences, Faculty of Medicine and Health Sciences, Ghent UniversityDepartment of Rehabilitation Sciences, Faculty of Medicine and Health Sciences, Ghent UniversityDepartment of Internal Medicine, Renal Division, Ghent University HospitalDepartment of Internal Medicine, Renal Division, Ghent University HospitalAbstract Background Impaired physical function due to muscle weakness and exercise intolerance reduces the ability to perform activities of daily living in patients with end-stage kidney disease, and by consequence, Health-Related Quality of Life (HRQoL). Furthermore, the risk of falls is an aggregate of physical function and, therefore, could be associated with HRQoL as well. The present study examined the associations between objective and subjective measures of physical function, risk of falls and HRQoL in haemodialysis patients. Methods This cross-sectional multicentre study included patients on maintenance haemodialysis. Physical function (quadriceps force, handgrip force, Sit-to-Stand, and six-minute walking test), the risk of falls (Tinetti, FICSIT-4, and dialysis fall index) and HRQoL (PROMIS-29 and EQ-5D-3 L) were measured and analysed descriptively, by general linear models and logistic regression. Results Of the 113 haemodialysis patients (mean age 67.5 ± 16.1, 57.5% male) enrolled, a majority had impaired quadriceps force (86.7%) and six-minute walking test (92%), and an increased risk of falls (73.5%). Whereas muscle strength and exercise capacity were associated with global HRQoL (R2 = 0.32) and the risk of falls, the risk of falls itself was related to psycho-social domains (R2 = 0.11) such as depression and social participation, rather than to the physical domains of HRQoL. Objective measures of physical function were not associated with subjective fatigue, nor with subjective appreciation of health status. Conclusions More than muscle strength, lack of coordination and balance as witnessed by the risk of falls contribute to social isolation and HRQoL of haemodialysis patients. Mental fatigue was less common than expected, whereas, subjective and objective physical function were decreased.https://doi.org/10.1186/s12882-019-1671-9End-stage kidney diseasePhysical functionRisk of fallsHaemodialysisQuality of life |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karsten Vanden Wyngaert Amaryllis H. Van Craenenbroeck Sunny Eloot Patrick Calders Bert Celie Els Holvoet Wim Van Biesen |
spellingShingle |
Karsten Vanden Wyngaert Amaryllis H. Van Craenenbroeck Sunny Eloot Patrick Calders Bert Celie Els Holvoet Wim Van Biesen Associations between the measures of physical function, risk of falls and the quality of life in haemodialysis patients: a cross-sectional study BMC Nephrology End-stage kidney disease Physical function Risk of falls Haemodialysis Quality of life |
author_facet |
Karsten Vanden Wyngaert Amaryllis H. Van Craenenbroeck Sunny Eloot Patrick Calders Bert Celie Els Holvoet Wim Van Biesen |
author_sort |
Karsten Vanden Wyngaert |
title |
Associations between the measures of physical function, risk of falls and the quality of life in haemodialysis patients: a cross-sectional study |
title_short |
Associations between the measures of physical function, risk of falls and the quality of life in haemodialysis patients: a cross-sectional study |
title_full |
Associations between the measures of physical function, risk of falls and the quality of life in haemodialysis patients: a cross-sectional study |
title_fullStr |
Associations between the measures of physical function, risk of falls and the quality of life in haemodialysis patients: a cross-sectional study |
title_full_unstemmed |
Associations between the measures of physical function, risk of falls and the quality of life in haemodialysis patients: a cross-sectional study |
title_sort |
associations between the measures of physical function, risk of falls and the quality of life in haemodialysis patients: a cross-sectional study |
publisher |
BMC |
series |
BMC Nephrology |
issn |
1471-2369 |
publishDate |
2020-01-01 |
description |
Abstract Background Impaired physical function due to muscle weakness and exercise intolerance reduces the ability to perform activities of daily living in patients with end-stage kidney disease, and by consequence, Health-Related Quality of Life (HRQoL). Furthermore, the risk of falls is an aggregate of physical function and, therefore, could be associated with HRQoL as well. The present study examined the associations between objective and subjective measures of physical function, risk of falls and HRQoL in haemodialysis patients. Methods This cross-sectional multicentre study included patients on maintenance haemodialysis. Physical function (quadriceps force, handgrip force, Sit-to-Stand, and six-minute walking test), the risk of falls (Tinetti, FICSIT-4, and dialysis fall index) and HRQoL (PROMIS-29 and EQ-5D-3 L) were measured and analysed descriptively, by general linear models and logistic regression. Results Of the 113 haemodialysis patients (mean age 67.5 ± 16.1, 57.5% male) enrolled, a majority had impaired quadriceps force (86.7%) and six-minute walking test (92%), and an increased risk of falls (73.5%). Whereas muscle strength and exercise capacity were associated with global HRQoL (R2 = 0.32) and the risk of falls, the risk of falls itself was related to psycho-social domains (R2 = 0.11) such as depression and social participation, rather than to the physical domains of HRQoL. Objective measures of physical function were not associated with subjective fatigue, nor with subjective appreciation of health status. Conclusions More than muscle strength, lack of coordination and balance as witnessed by the risk of falls contribute to social isolation and HRQoL of haemodialysis patients. Mental fatigue was less common than expected, whereas, subjective and objective physical function were decreased. |
topic |
End-stage kidney disease Physical function Risk of falls Haemodialysis Quality of life |
url |
https://doi.org/10.1186/s12882-019-1671-9 |
work_keys_str_mv |
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