One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids

One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids

Palladium–catalyzed Suzuki cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with excess arylboronic acids (2.5 equiv.) in the presence of tricyclohexylphosphine afforded the 2,3,4-triarylquinolines in one-pot operation. The incipient 2,3-diaryl-4-chloroquinolines were also prepared and transformed...

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Bibliographic Details
Main Authors: Malose Jack Mphahlele, Mamasegare Mabel Mphahlele
Format: Article
Language:English
Published: MDPI AG 2010-10-01
Series:Molecules
Subjects:
2-aryl-4-chloro-3-iodoquinolines
Suzuki-Miyaura cross-coupling
2,3-diaryl-4-chloroquinolines
2,3,4-triarylquinolines
Online Access:http://www.mdpi.com/1420-3049/15/10/7423/
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spelling doaj-fb3aa23b9a74417284996b297f6c8d862020-11-25T00:38:17ZengMDPI AGMolecules1420-30492010-10-01151074237437One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic AcidsMalose Jack MphahleleMamasegare Mabel MphahlelePalladium–catalyzed Suzuki cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with excess arylboronic acids (2.5 equiv.) in the presence of tricyclohexylphosphine afforded the 2,3,4-triarylquinolines in one-pot operation. The incipient 2,3-diaryl-4-chloroquinolines were also prepared and transformed to the primary 4-amino-2,3-diarylquinolines and 2,3-diarylquinolin-4(1H)-ones. http://www.mdpi.com/1420-3049/15/10/7423/2-aryl-4-chloro-3-iodoquinolinesSuzuki-Miyaura cross-coupling2,3-diaryl-4-chloroquinolines2,3,4-triarylquinolines
collection DOAJ
language English
format Article
sources DOAJ
author Malose Jack Mphahlele
Mamasegare Mabel Mphahlele
spellingShingle Malose Jack Mphahlele
Mamasegare Mabel Mphahlele
One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids
Molecules
2-aryl-4-chloro-3-iodoquinolines
Suzuki-Miyaura cross-coupling
2,3-diaryl-4-chloroquinolines
2,3,4-triarylquinolines
author_facet Malose Jack Mphahlele
Mamasegare Mabel Mphahlele
author_sort Malose Jack Mphahlele
title One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids
title_short One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids
title_full One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids
title_fullStr One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids
title_full_unstemmed One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids
title_sort one-pot synthesis of 2,3,4-triarylquinolines via suzuki-miyaura cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with arylboronic acids
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2010-10-01
description Palladium–catalyzed Suzuki cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with excess arylboronic acids (2.5 equiv.) in the presence of tricyclohexylphosphine afforded the 2,3,4-triarylquinolines in one-pot operation. The incipient 2,3-diaryl-4-chloroquinolines were also prepared and transformed to the primary 4-amino-2,3-diarylquinolines and 2,3-diarylquinolin-4(1H)-ones.
topic 2-aryl-4-chloro-3-iodoquinolines
Suzuki-Miyaura cross-coupling
2,3-diaryl-4-chloroquinolines
2,3,4-triarylquinolines
url http://www.mdpi.com/1420-3049/15/10/7423/
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AT mamasegaremabelmphahlele onepotsynthesisof234triarylquinolinesviasuzukimiyauracrosscouplingof2aryl4chloro3iodoquinolineswitharylboronicacids
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