DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review

DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in regulating gene expression. The epigenetic component is strongly involved in aging-bone diseases, such as osteoporosis and osteoarthritis. Both are complex multi-factorial late-onset disorders that represent...

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Main Authors: Virginia Veronica Visconti, Ida Cariati, Simona Fittipaldi, Riccardo Iundusi, Elena Gasbarra, Umberto Tarantino, Annalisa Botta
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
epigenetics
DNA methylation
bone metabolism
osteoporosis
osteoarthritis
aging-related diseases
Online Access:https://www.mdpi.com/1422-0067/22/8/4244
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spelling doaj-fb41b486a1794b9ba1360ddbaf67c9ff2021-04-19T23:05:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01224244424410.3390/ijms22084244DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated ReviewVirginia Veronica Visconti0Ida Cariati1Simona Fittipaldi2Riccardo Iundusi3Elena Gasbarra4Umberto Tarantino5Annalisa Botta6Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyDepartment of Orthopaedics and Traumatology, “Policlinico Tor Vergata” Foundation, Viale Oxford 81, 00133 Rome, ItalyDepartment of Orthopaedics and Traumatology, “Policlinico Tor Vergata” Foundation, Viale Oxford 81, 00133 Rome, ItalyDepartment of Orthopaedics and Traumatology, “Policlinico Tor Vergata” Foundation, Viale Oxford 81, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyDNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in regulating gene expression. The epigenetic component is strongly involved in aging-bone diseases, such as osteoporosis and osteoarthritis. Both are complex multi-factorial late-onset disorders that represent a globally widespread health problem, highlighting a crucial point of investigations in many scientific studies. In recent years, new findings on the role of DNA methylation in the pathogenesis of aging-bone diseases have emerged. The aim of this systematic review is to update knowledge in the field of DNA methylation associated with osteoporosis and osteoarthritis, focusing on the specific tissues involved in both pathological conditions.https://www.mdpi.com/1422-0067/22/8/4244epigeneticsDNA methylationbone metabolismosteoporosisosteoarthritisaging-related diseases
collection DOAJ
language English
format Article
sources DOAJ
author Virginia Veronica Visconti
Ida Cariati
Simona Fittipaldi
Riccardo Iundusi
Elena Gasbarra
Umberto Tarantino
Annalisa Botta
spellingShingle Virginia Veronica Visconti
Ida Cariati
Simona Fittipaldi
Riccardo Iundusi
Elena Gasbarra
Umberto Tarantino
Annalisa Botta
DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review
International Journal of Molecular Sciences
epigenetics
DNA methylation
bone metabolism
osteoporosis
osteoarthritis
aging-related diseases
author_facet Virginia Veronica Visconti
Ida Cariati
Simona Fittipaldi
Riccardo Iundusi
Elena Gasbarra
Umberto Tarantino
Annalisa Botta
author_sort Virginia Veronica Visconti
title DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review
title_short DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review
title_full DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review
title_fullStr DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review
title_full_unstemmed DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review
title_sort dna methylation signatures of bone metabolism in osteoporosis and osteoarthritis aging-related diseases: an updated review
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-04-01
description DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in regulating gene expression. The epigenetic component is strongly involved in aging-bone diseases, such as osteoporosis and osteoarthritis. Both are complex multi-factorial late-onset disorders that represent a globally widespread health problem, highlighting a crucial point of investigations in many scientific studies. In recent years, new findings on the role of DNA methylation in the pathogenesis of aging-bone diseases have emerged. The aim of this systematic review is to update knowledge in the field of DNA methylation associated with osteoporosis and osteoarthritis, focusing on the specific tissues involved in both pathological conditions.
topic epigenetics
DNA methylation
bone metabolism
osteoporosis
osteoarthritis
aging-related diseases
url https://www.mdpi.com/1422-0067/22/8/4244
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AT simonafittipaldi dnamethylationsignaturesofbonemetabolisminosteoporosisandosteoarthritisagingrelateddiseasesanupdatedreview
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