Awareness of Cognitive Decline in Patients With Alzheimer's Disease: A Systematic Review and Meta-Analysis
Background: Identifying a poor degree of awareness of cognitive decline (ACD) could represent an early indicator of Alzheimer's disease (AD).Objectives: (1) to understand whether there is evidence of poor ACD in the pre-dementia stages of AD; (2) to summarize the main findings obtained investig...
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Frontiers Media S.A.
2021-08-01
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Series: | Frontiers in Aging Neuroscience |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.697234/full |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Federica Cacciamani Federica Cacciamani Federica Cacciamani Federica Cacciamani Federica Cacciamani Marion Houot Marion Houot Marion Houot Geoffroy Gagliardi Geoffroy Gagliardi Bruno Dubois Bruno Dubois Bruno Dubois Bruno Dubois Bruno Dubois Sietske Sikkes Sietske Sikkes Gonzalo Sánchez-Benavides Gonzalo Sánchez-Benavides Gonzalo Sánchez-Benavides Elena Denicolò José Luis Molinuevo Patrizia Vannini Patrizia Vannini Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum |
spellingShingle |
Federica Cacciamani Federica Cacciamani Federica Cacciamani Federica Cacciamani Federica Cacciamani Marion Houot Marion Houot Marion Houot Geoffroy Gagliardi Geoffroy Gagliardi Bruno Dubois Bruno Dubois Bruno Dubois Bruno Dubois Bruno Dubois Sietske Sikkes Sietske Sikkes Gonzalo Sánchez-Benavides Gonzalo Sánchez-Benavides Gonzalo Sánchez-Benavides Elena Denicolò José Luis Molinuevo Patrizia Vannini Patrizia Vannini Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum Awareness of Cognitive Decline in Patients With Alzheimer's Disease: A Systematic Review and Meta-Analysis Frontiers in Aging Neuroscience awareness anosognosia metamemory hypernosognosia Alzheimer's disease |
author_facet |
Federica Cacciamani Federica Cacciamani Federica Cacciamani Federica Cacciamani Federica Cacciamani Marion Houot Marion Houot Marion Houot Geoffroy Gagliardi Geoffroy Gagliardi Bruno Dubois Bruno Dubois Bruno Dubois Bruno Dubois Bruno Dubois Sietske Sikkes Sietske Sikkes Gonzalo Sánchez-Benavides Gonzalo Sánchez-Benavides Gonzalo Sánchez-Benavides Elena Denicolò José Luis Molinuevo Patrizia Vannini Patrizia Vannini Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum |
author_sort |
Federica Cacciamani |
title |
Awareness of Cognitive Decline in Patients With Alzheimer's Disease: A Systematic Review and Meta-Analysis |
title_short |
Awareness of Cognitive Decline in Patients With Alzheimer's Disease: A Systematic Review and Meta-Analysis |
title_full |
Awareness of Cognitive Decline in Patients With Alzheimer's Disease: A Systematic Review and Meta-Analysis |
title_fullStr |
Awareness of Cognitive Decline in Patients With Alzheimer's Disease: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
Awareness of Cognitive Decline in Patients With Alzheimer's Disease: A Systematic Review and Meta-Analysis |
title_sort |
awareness of cognitive decline in patients with alzheimer's disease: a systematic review and meta-analysis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2021-08-01 |
description |
Background: Identifying a poor degree of awareness of cognitive decline (ACD) could represent an early indicator of Alzheimer's disease (AD).Objectives: (1) to understand whether there is evidence of poor ACD in the pre-dementia stages of AD; (2) to summarize the main findings obtained investigating ACD in AD; (3) to propose a conceptual framework.Data Sources: We searched Scopus, Pubmed, and the reference lists for studies published up to August 2020. Original research articles must report a measure of ACD and included individuals with AD dementia, or prodromal AD (or MCI), or being at risk for AD.Data Synthesis: All studies covering preclinical, prodromal, and AD dementia were systematically reviewed. We intended to perform a meta-analysis of empirical studies on preclinical AD or prodromal AD (or MCI), to compare ACD between clinical groups. Due to the paucity of literature on preclinical AD, meta-analysis was only possible for prodromal AD (or MCI) studies.Results: We systematically reviewed 283 articles, and conducted a meta-analysis of 18 articles on prodromal AD (or MCI), showing that ACD was not significantly different between patients with amnestic and non-amnestic MCI (SMD = 0.09, p = 0.574); ACD was significantly poorer in amnestic MCI (SMD = −0.56, p = 0.001) and mild AD (SMD = −1.39, p < 0.001) than in controls; ACD was also significantly poorer in mild AD than in amnestic MCI (SMD = −0.75, p < 0.001), as well as poorer than in non-amnestic MCI (SMD = −1.00, p < 0.001). We also discuss key findings on ACD in AD, such as its neural and cognitive correlates.Conclusions and Implications: We propose that patients may be complaining of their initial subtle cognitive changes, but ACD would soon start to decrease. The individual would show mild anosognosia in the MCI stage, and severe anosognosia in dementia. The evaluation of ACD (comparing self-report to cognitive scores or to informant-report) could be useful to guide the clinician toward a timely diagnosis, and in trials targeting early-stage AD. |
topic |
awareness anosognosia metamemory hypernosognosia Alzheimer's disease |
url |
https://www.frontiersin.org/articles/10.3389/fnagi.2021.697234/full |
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doaj-fb4c676e287a419992c1cf6df28fa8f02021-08-03T16:50:06ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-08-011310.3389/fnagi.2021.697234697234Awareness of Cognitive Decline in Patients With Alzheimer's Disease: A Systematic Review and Meta-AnalysisFederica Cacciamani0Federica Cacciamani1Federica Cacciamani2Federica Cacciamani3Federica Cacciamani4Marion Houot5Marion Houot6Marion Houot7Geoffroy Gagliardi8Geoffroy Gagliardi9Bruno Dubois10Bruno Dubois11Bruno Dubois12Bruno Dubois13Bruno Dubois14Sietske Sikkes15Sietske Sikkes16Gonzalo Sánchez-Benavides17Gonzalo Sánchez-Benavides18Gonzalo Sánchez-Benavides19Elena Denicolò20José Luis Molinuevo21Patrizia Vannini22Patrizia Vannini23Stéphane Epelbaum24Stéphane Epelbaum25Stéphane Epelbaum26Stéphane Epelbaum27Stéphane Epelbaum28Stéphane Epelbaum29Institut du Cerveau, ICM, Hôpital de la Pitié-Salpêtrière, Paris, FranceInserm, U 1127, Paris, FranceCNRS, UMR 7225, Paris, FranceSorbonne Université, Paris, FranceInria, ARAMIS-Project Team, Paris, FranceInstitut du Cerveau, ICM, Hôpital de la Pitié-Salpêtrière, Paris, FranceSorbonne Université, Paris, FranceInstitute of Memory and Alzheimer's Disease (IM2A), Centre of Excellence of Neurodegenerative Disease (CoEN), ICM, CIC Neurosciences, AP-HP, Department of Neurology, Hôpital de la Pitié-Salpêtrière, Sorbonne University, Paris, FranceDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesDepartment of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United StatesInstitut du Cerveau, ICM, Hôpital de la Pitié-Salpêtrière, Paris, FranceInserm, U 1127, Paris, FranceCNRS, UMR 7225, Paris, FranceSorbonne Université, Paris, FranceInstitute of Memory and Alzheimer's Disease (IM2A), Centre of Excellence of Neurodegenerative Disease (CoEN), ICM, CIC Neurosciences, AP-HP, Department of Neurology, Hôpital de la Pitié-Salpêtrière, Sorbonne University, Paris, FranceDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center (UMC), Vrije Universiteit Amsterdam, Amsterdam, Netherlands0BarcelonaBeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain1Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain2Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain3Department of Biomedical Science and Neuromotor Sciences, University of Bologna, Bologna, Italy0BarcelonaBeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, SpainDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesDepartment of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United StatesInstitut du Cerveau, ICM, Hôpital de la Pitié-Salpêtrière, Paris, FranceInserm, U 1127, Paris, FranceCNRS, UMR 7225, Paris, FranceSorbonne Université, Paris, FranceInria, ARAMIS-Project Team, Paris, FranceInstitute of Memory and Alzheimer's Disease (IM2A), Centre of Excellence of Neurodegenerative Disease (CoEN), ICM, CIC Neurosciences, AP-HP, Department of Neurology, Hôpital de la Pitié-Salpêtrière, Sorbonne University, Paris, FranceBackground: Identifying a poor degree of awareness of cognitive decline (ACD) could represent an early indicator of Alzheimer's disease (AD).Objectives: (1) to understand whether there is evidence of poor ACD in the pre-dementia stages of AD; (2) to summarize the main findings obtained investigating ACD in AD; (3) to propose a conceptual framework.Data Sources: We searched Scopus, Pubmed, and the reference lists for studies published up to August 2020. Original research articles must report a measure of ACD and included individuals with AD dementia, or prodromal AD (or MCI), or being at risk for AD.Data Synthesis: All studies covering preclinical, prodromal, and AD dementia were systematically reviewed. We intended to perform a meta-analysis of empirical studies on preclinical AD or prodromal AD (or MCI), to compare ACD between clinical groups. Due to the paucity of literature on preclinical AD, meta-analysis was only possible for prodromal AD (or MCI) studies.Results: We systematically reviewed 283 articles, and conducted a meta-analysis of 18 articles on prodromal AD (or MCI), showing that ACD was not significantly different between patients with amnestic and non-amnestic MCI (SMD = 0.09, p = 0.574); ACD was significantly poorer in amnestic MCI (SMD = −0.56, p = 0.001) and mild AD (SMD = −1.39, p < 0.001) than in controls; ACD was also significantly poorer in mild AD than in amnestic MCI (SMD = −0.75, p < 0.001), as well as poorer than in non-amnestic MCI (SMD = −1.00, p < 0.001). We also discuss key findings on ACD in AD, such as its neural and cognitive correlates.Conclusions and Implications: We propose that patients may be complaining of their initial subtle cognitive changes, but ACD would soon start to decrease. The individual would show mild anosognosia in the MCI stage, and severe anosognosia in dementia. The evaluation of ACD (comparing self-report to cognitive scores or to informant-report) could be useful to guide the clinician toward a timely diagnosis, and in trials targeting early-stage AD.https://www.frontiersin.org/articles/10.3389/fnagi.2021.697234/fullawarenessanosognosiametamemoryhypernosognosiaAlzheimer's disease |