Perspective: The promise of multi-cellular engineered living systems
Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of pot...
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AIP Publishing LLC
2018-12-01
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| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/1.5038337 |
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doaj-fb4c6fc57d0444e39750e5d912c2d6de2020-11-25T00:36:12ZengAIP Publishing LLCAPL Bioengineering2473-28772018-12-0124040901040901-2110.1063/1.5038337001804APBPerspective: The promise of multi-cellular engineered living systemsRoger D. Kamm0Rashid Bashir1Natasha Arora2Roy D. Dar3Martha U. Gillette4Linda G. Griffith5Melissa L. Kemp6Kathy Kinlaw7Michael Levin8Adam C. Martin9Todd C. McDevitt10Robert M. Nerem11Mark J. Powers12Taher A. Saif13James Sharpe14Shuichi Takayama15Shoji Takeuchi16Ron Weiss17Kaiming Ye18Hannah G. Yevick19Muhammad H. Zaman20 Massachusetts Institute of Technology, Boston, Massachusetts 02139, USA University of Illinois at Urbana-Champaign, Urbana, Illinois 61820, USA Massachusetts Institute of Technology, Boston, Massachusetts 02139, USA University of Illinois at Urbana-Champaign, Urbana, Illinois 61820, USA University of Illinois at Urbana-Champaign, Urbana, Illinois 61820, USA Massachusetts Institute of Technology, Boston, Massachusetts 02139, USA Georgia Institute of Technology, Atlanta, Georgia 30332, USA Emory University, Atlanta, Georgia 30322, USA Tufts University, Boston, Massachusetts 02153, USA Massachusetts Institute of Technology, Boston, Massachusetts 02139, USA Gladstone Institutes, San Francisco, California 94158, USA Georgia Institute of Technology, Atlanta, Georgia 30332, USA Thermo Fisher Scientific, Frederick, Maryland 21704, USA University of Illinois at Urbana-Champaign, Urbana, Illinois 61820, USA EMBL Barcelona, European Molecular Biology Laboratory, Barcelona 08003, Spain Georgia Institute of Technology, Atlanta, Georgia 30332, USA The University of Tokyo, Tokyo 113-8654, Japan Massachusetts Institute of Technology, Boston, Massachusetts 02139, USA Binghamton University, Binghamton, New York 13902, USA Massachusetts Institute of Technology, Boston, Massachusetts 02139, USA Boston University, Boston, Massachusetts 02215, USARecent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of potential uses. This white paper summarizes the state of the emerging field of “multi-cellular engineered living systems,” which are composed of interacting cell populations. Recent accomplishments are described, focusing on current and potential applications, as well as barriers to future advances, and the outlook for longer term benefits and potential ethical issues that need to be considered.http://dx.doi.org/10.1063/1.5038337 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Roger D. Kamm Rashid Bashir Natasha Arora Roy D. Dar Martha U. Gillette Linda G. Griffith Melissa L. Kemp Kathy Kinlaw Michael Levin Adam C. Martin Todd C. McDevitt Robert M. Nerem Mark J. Powers Taher A. Saif James Sharpe Shuichi Takayama Shoji Takeuchi Ron Weiss Kaiming Ye Hannah G. Yevick Muhammad H. Zaman |
| spellingShingle |
Roger D. Kamm Rashid Bashir Natasha Arora Roy D. Dar Martha U. Gillette Linda G. Griffith Melissa L. Kemp Kathy Kinlaw Michael Levin Adam C. Martin Todd C. McDevitt Robert M. Nerem Mark J. Powers Taher A. Saif James Sharpe Shuichi Takayama Shoji Takeuchi Ron Weiss Kaiming Ye Hannah G. Yevick Muhammad H. Zaman Perspective: The promise of multi-cellular engineered living systems APL Bioengineering |
| author_facet |
Roger D. Kamm Rashid Bashir Natasha Arora Roy D. Dar Martha U. Gillette Linda G. Griffith Melissa L. Kemp Kathy Kinlaw Michael Levin Adam C. Martin Todd C. McDevitt Robert M. Nerem Mark J. Powers Taher A. Saif James Sharpe Shuichi Takayama Shoji Takeuchi Ron Weiss Kaiming Ye Hannah G. Yevick Muhammad H. Zaman |
| author_sort |
Roger D. Kamm |
| title |
Perspective: The promise of multi-cellular engineered living systems |
| title_short |
Perspective: The promise of multi-cellular engineered living systems |
| title_full |
Perspective: The promise of multi-cellular engineered living systems |
| title_fullStr |
Perspective: The promise of multi-cellular engineered living systems |
| title_full_unstemmed |
Perspective: The promise of multi-cellular engineered living systems |
| title_sort |
perspective: the promise of multi-cellular engineered living systems |
| publisher |
AIP Publishing LLC |
| series |
APL Bioengineering |
| issn |
2473-2877 |
| publishDate |
2018-12-01 |
| description |
Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of potential uses. This white paper summarizes the state of the emerging field of “multi-cellular engineered living systems,” which are composed of interacting cell populations. Recent accomplishments are described, focusing on current and potential applications, as well as barriers to future advances, and the outlook for longer term benefits and potential ethical issues that need to be considered. |
| url |
http://dx.doi.org/10.1063/1.5038337 |
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