Biomimetic restoration and regeneration of dentin and cementum

• Main Authors: WANG Jue, WANG Qian, WU Jia, LI Lingfeng, SUI Xin, LI Meihui, ZHANG Xiao, GAO Ying, YANG Liuqing, LIU Zhihui
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases 2021-06-01
• Series: 口腔疾病防治
• Subjects: dentin，; cementum，; demineralization，; remineralization，; biomimetic restoration，; regeneration，; hydroxyapatite，; collagen fibers，; amorphous calcium phosphate ，; polymer-induced liquid precursor，
• Online Access: http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2021.06.011

Dental hard tissues lack the ability to self-heal. In dentin and cementum, hydroxyapatite (HA) can exist outside and/or inside collagen fibers. It is difficult to repair or regenerate HA with a highly ordered orientation in the presence of collagen fibers. At present, the biomimetic mineralization of dentin and cementum, mainly carried out by imitating its biological formation process and its physiological structure, can be divided into those originating from the fiber mineralization mechanism and those with HA as the main component. The materials used include natural materials such as demineralized dentin matrix (DDM) and calcined bovine hydroxyapatite (BHA), and synthetic materials such as polymer-induced liquid precursor (PILP) and synthetic HA. In the future, natural materials and synthetic materials should be combined for the restoration and regeneration of dentin and cementum by means of biomimetic mineralization of calcium phosphate released by remineralization solution-HA.