Identification of circulating sphingosine kinase-related metabolites for prediction of type 2 diabetes

Identification of circulating sphingosine kinase-related metabolites for prediction of type 2 diabetes

Abstract Background Sphingosine Kinase (SphK) that catalyzes sphingosine (Sph) to sphingosine 1-phosphate (S1P), plays a key role in both sphingolipid metabolism and cellular signaling. While SphK has been implicated in type 2 diabetes mellitus (T2DM), it is unexplored in humans. Herein, we investig...

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Bibliographic Details
Main Authors: Qi Chen, Wei Wang, Ming-Feng Xia, You-li Lu, Hua Bian, Chen Yu, Xiao-Ying Li, Mathew A. Vadas, Xin Gao, Huan-Dong Lin, Pu Xia
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Translational Medicine
Online Access:https://doi.org/10.1186/s12967-021-03066-z

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