Overrunning in clinical trials: some thoughts from a methodological review
Abstract Background In sequential and adaptive trials, the delay that happens after the trial is stopped, by a predetermined stopping criterion, takes the name of overrunning. Overrunning consists of extra data, collected by investigators while awaiting results of the interim analysis (IA). The incl...
Main Authors: | Ileana Baldi, Danila Azzolina, Nicola Soriani, Beatrice Barbetta, Paola Vaghi, Giampaolo Giacovelli, Paola Berchialla, Dario Gregori |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-07-01
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Series: | Trials |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13063-020-04526-5 |
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