Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery
<p>Abstract</p> <p>Background</p> <p>Phosphoinositide lipid kinases (PIKs) generate specific phosphorylated variants of phosatidylinositols (PtdIns) that are critical for second messenger signaling and cellular membrane remodeling. Mammals have 19 PIK isoforms spread ac...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
BMC
2011-01-01
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Series: | BMC Evolutionary Biology |
Online Access: | http://www.biomedcentral.com/1471-2148/11/4 |