Microbiota in Healthy Skin and in Atopic Eczema
The Italian interest group (IG) on atopic eczema and urticaria is member of the Italian Society of Allergology and Immunology. The aim of our IG is to provide a platform for scientists, clinicians, and experts. In this review we discuss the role of skin microbiota not only in healthy skin but also i...
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Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2014/436921 |
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doaj-fb87c8e824bd481f85c4e006d162d8202020-11-25T00:04:26ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/436921436921Microbiota in Healthy Skin and in Atopic EczemaGiuseppe Baviera0Maria Chiara Leoni1Lucetta Capra2Francesca Cipriani3Giorgio Longo4Nunzia Maiello5Giampaolo Ricci6Elena Galli7National Health System Pediatrician ASL RMC-D6, Rome, ItalyItalian Society of Pediatric Allergy and Immunology (SIAIP), Atopic Dermatitis and Urticaria Committee, ItalyItalian Society of Pediatric Allergy and Immunology (SIAIP), Atopic Dermatitis and Urticaria Committee, ItalyItalian Society of Pediatric Allergy and Immunology (SIAIP), Atopic Dermatitis and Urticaria Committee, ItalyItalian Society of Pediatric Allergy and Immunology (SIAIP), Atopic Dermatitis and Urticaria Committee, ItalyItalian Society of Pediatric Allergy and Immunology (SIAIP), Atopic Dermatitis and Urticaria Committee, ItalyItalian Society of Pediatric Allergy and Immunology (SIAIP), Atopic Dermatitis and Urticaria Committee, ItalyItalian Society of Pediatric Allergy and Immunology (SIAIP), Atopic Dermatitis and Urticaria Committee, ItalyThe Italian interest group (IG) on atopic eczema and urticaria is member of the Italian Society of Allergology and Immunology. The aim of our IG is to provide a platform for scientists, clinicians, and experts. In this review we discuss the role of skin microbiota not only in healthy skin but also in skin suffering from atopic dermatitis (AD). A Medline and Embase search was conducted for studies evaluating the role of skin microbiota. We examine microbiota composition and its development within days after birth; we describe the role of specific groups of microorganisms that colonize distinct anatomical niches and the biology and clinical relevance of antimicrobial peptides expressed in the skin. Specific AD disease states are characterized by concurrent and anticorrelated shifts in microbial diversity and proportion of Staphylococcus. These organisms may protect the host, defining them not as simple symbiotic microbes but rather as mutualistic microbes. These findings reveal links between microbial communities and inflammatory diseases such as AD and provide novel insights into global shifts of bacteria relevant to disease progression and treatment. This review also highlights recent observations on the importance of innate immune systems and the relationship with normal skin microflora for the maintenance of healthy skin.http://dx.doi.org/10.1155/2014/436921 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giuseppe Baviera Maria Chiara Leoni Lucetta Capra Francesca Cipriani Giorgio Longo Nunzia Maiello Giampaolo Ricci Elena Galli |
spellingShingle |
Giuseppe Baviera Maria Chiara Leoni Lucetta Capra Francesca Cipriani Giorgio Longo Nunzia Maiello Giampaolo Ricci Elena Galli Microbiota in Healthy Skin and in Atopic Eczema BioMed Research International |
author_facet |
Giuseppe Baviera Maria Chiara Leoni Lucetta Capra Francesca Cipriani Giorgio Longo Nunzia Maiello Giampaolo Ricci Elena Galli |
author_sort |
Giuseppe Baviera |
title |
Microbiota in Healthy Skin and in Atopic Eczema |
title_short |
Microbiota in Healthy Skin and in Atopic Eczema |
title_full |
Microbiota in Healthy Skin and in Atopic Eczema |
title_fullStr |
Microbiota in Healthy Skin and in Atopic Eczema |
title_full_unstemmed |
Microbiota in Healthy Skin and in Atopic Eczema |
title_sort |
microbiota in healthy skin and in atopic eczema |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
The Italian interest group (IG) on atopic eczema and urticaria is member of the Italian Society of Allergology and Immunology. The aim of our IG is to provide a platform for scientists, clinicians, and experts. In this review we discuss the role of skin microbiota not only in healthy skin but also in skin suffering from atopic dermatitis (AD). A Medline and Embase search was conducted for studies evaluating the role of skin microbiota. We examine microbiota composition and its development within days after birth; we describe the role of specific groups of microorganisms that colonize distinct anatomical niches and the biology and clinical relevance of antimicrobial peptides expressed in the skin. Specific AD disease states are characterized by concurrent and anticorrelated shifts in microbial diversity and proportion of Staphylococcus. These organisms may protect the host, defining them not as simple symbiotic microbes but rather as mutualistic microbes. These findings reveal links between microbial communities and inflammatory diseases such as AD and provide novel insights into global shifts of bacteria relevant to disease progression and treatment. This review also highlights recent observations on the importance of innate immune systems and the relationship with normal skin microflora for the maintenance of healthy skin. |
url |
http://dx.doi.org/10.1155/2014/436921 |
work_keys_str_mv |
AT giuseppebaviera microbiotainhealthyskinandinatopiceczema AT mariachiaraleoni microbiotainhealthyskinandinatopiceczema AT lucettacapra microbiotainhealthyskinandinatopiceczema AT francescacipriani microbiotainhealthyskinandinatopiceczema AT giorgiolongo microbiotainhealthyskinandinatopiceczema AT nunziamaiello microbiotainhealthyskinandinatopiceczema AT giampaoloricci microbiotainhealthyskinandinatopiceczema AT elenagalli microbiotainhealthyskinandinatopiceczema |
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1725429237609922560 |