Experimental autoimmune uveitis and other animal models of uveitis: An update
Over the past several decades, animal models of autoimmune uveitis directed at eye-specific antigens (Ags) have been developed. These have allowed researchers to understand the basic mechanisms that lead to these diseases and also recently helped the researchers in translational research for therape...
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doaj-fb8967bc77db44288f6141a973c3973c2020-11-24T23:47:12ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892015-01-0163321121810.4103/0301-4738.156914Experimental autoimmune uveitis and other animal models of uveitis: An updateSvati BansalVeluchamy A BarathiDaiju IwataRupesh AgrawalOver the past several decades, animal models of autoimmune uveitis directed at eye-specific antigens (Ags) have been developed. These have allowed researchers to understand the basic mechanisms that lead to these diseases and also recently helped the researchers in translational research for therapeutic interventions. Experimental autoimmune uveitis (EAU) is an animal disease model of human endogenous uveitis and can be induced in susceptible animals by immunization with retinal Ags. Ever since the first description of EAU in mice in 1988, several animal models of uveitis has been described by researchers. Disease-specific model for cytomegalovirus retinitis and tubercular uveitis has evolved our understanding of these complex entities. Endotoxin induced uveitis is another useful model for anterior uveitis, which is not an autoimmune process and is triggered by injection of bacterial endotoxin (lipopolysaccharides) resulting in a rapid short lasting uveitis. The current article will give an insight into the various EAU animal models and their current implications in translational research. The article will also highlight the different grading systems for EAU in the animal model.http://www.ijo.in/article.asp?issn=0301-4738;year=2015;volume=63;issue=3;spage=211;epage=218;aulast=BansalIntraocularlymphomaretinavitreous Conjunctivacornealymphomamelanomaocular surfaceocular surface squamous neoplasiatumorBrachytherapychemotherapycryopexyintra ocular tumorsphotocoagulationAnimal uveitis modelcytomegalovirus retinitis animal modelendotoxin-induced uveitisexperimental autoimmune uveitisspontaneoustubercular uveitis animal model |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Svati Bansal Veluchamy A Barathi Daiju Iwata Rupesh Agrawal |
spellingShingle |
Svati Bansal Veluchamy A Barathi Daiju Iwata Rupesh Agrawal Experimental autoimmune uveitis and other animal models of uveitis: An update Indian Journal of Ophthalmology Intraocular lymphoma retina vitreous Conjunctiva cornea lymphoma melanoma ocular surface ocular surface squamous neoplasia tumor Brachytherapy chemotherapy cryopexy intra ocular tumors photocoagulation Animal uveitis model cytomegalovirus retinitis animal model endotoxin-induced uveitis experimental autoimmune uveitis spontaneous tubercular uveitis animal model |
author_facet |
Svati Bansal Veluchamy A Barathi Daiju Iwata Rupesh Agrawal |
author_sort |
Svati Bansal |
title |
Experimental autoimmune uveitis and other animal models of uveitis: An update |
title_short |
Experimental autoimmune uveitis and other animal models of uveitis: An update |
title_full |
Experimental autoimmune uveitis and other animal models of uveitis: An update |
title_fullStr |
Experimental autoimmune uveitis and other animal models of uveitis: An update |
title_full_unstemmed |
Experimental autoimmune uveitis and other animal models of uveitis: An update |
title_sort |
experimental autoimmune uveitis and other animal models of uveitis: an update |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Ophthalmology |
issn |
0301-4738 1998-3689 |
publishDate |
2015-01-01 |
description |
Over the past several decades, animal models of autoimmune uveitis directed at eye-specific antigens (Ags) have been developed. These have allowed researchers to understand the basic mechanisms that lead to these diseases and also recently helped the researchers in translational research for therapeutic interventions. Experimental autoimmune uveitis (EAU) is an animal disease model of human endogenous uveitis and can be induced in susceptible animals by immunization with retinal Ags. Ever since the first description of EAU in mice in 1988, several animal models of uveitis has been described by researchers. Disease-specific model for cytomegalovirus retinitis and tubercular uveitis has evolved our understanding of these complex entities. Endotoxin induced uveitis is another useful model for anterior uveitis, which is not an autoimmune process and is triggered by injection of bacterial endotoxin (lipopolysaccharides) resulting in a rapid short lasting uveitis. The current article will give an insight into the various EAU animal models and their current implications in translational research. The article will also highlight the different grading systems for EAU in the animal model. |
topic |
Intraocular lymphoma retina vitreous Conjunctiva cornea lymphoma melanoma ocular surface ocular surface squamous neoplasia tumor Brachytherapy chemotherapy cryopexy intra ocular tumors photocoagulation Animal uveitis model cytomegalovirus retinitis animal model endotoxin-induced uveitis experimental autoimmune uveitis spontaneous tubercular uveitis animal model |
url |
http://www.ijo.in/article.asp?issn=0301-4738;year=2015;volume=63;issue=3;spage=211;epage=218;aulast=Bansal |
work_keys_str_mv |
AT svatibansal experimentalautoimmuneuveitisandotheranimalmodelsofuveitisanupdate AT veluchamyabarathi experimentalautoimmuneuveitisandotheranimalmodelsofuveitisanupdate AT daijuiwata experimentalautoimmuneuveitisandotheranimalmodelsofuveitisanupdate AT rupeshagrawal experimentalautoimmuneuveitisandotheranimalmodelsofuveitisanupdate |
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