Impact of aqueous bark extract of Terminalia arjuna on hematological and immunological profile variables of albino rats

• Main Authors: Priyanka Sagar, Manoranjan Prasad Sinha, Manoj Kumar
• Format: Article
• Language: English
• Published: Romanian Association of Balneology, Editura Balneara 2016-02-01
• Series: Balneo Research Journal
• Subjects: IgG; IgA; IgM; Terminalia arjuna; Hematological
• Online Access: http://bioclima.ro/Balneo113.pdf
• ISSN: 2069-7597; 2069-7619

ABSTRACT The effect of aqueous extract of bark of Terminalia arjuna on some hematlogical and immunological parameters in rats during a seven-day administration of the doses of 250mg/kg and 500 mg/kg body weight orally was investigated. The results showed significant increase in total leucocyte count, monocytes, eosinophil, monocytes, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, and mean corp. hemo. Conc, and platelet count in both the cases, when it was treated with low doses and high doses but in neutrophil, hematocrit significantly increased in case of low doses and reduced significantly with high doses and lymphocyte reduced with low doses and significantly increased in case of high doses. In Immunology, the IGG count showed no significant change in low dose, high dose as compared to control and non-significant changes when low dose compared to high dose. The IGM count showed significant changes in low dose, as compared to control; increased significantly in high dose, compared to control and non-significant changes observed in low dose as compared to high dose. The IGA count showed no significant changes when low dose, high dose was compared to control but increased significantly, when low dose compared to high dose. The results of this study suggest that the extracts showed beneficial effects on hematology and immunity related disorders and can be used in medicinal formulations.