COMPARATIVE EVALUATION OF TACROLIMUS 0.03% OINTMENT VS OLOPATADINE 0.2% EYE DROPS IN THE TREATMENT OF VERNAL KERATOCONJUNCTIVITIS
Objective: To compare the efficacy of tacrolimus 0.03% ointment to olopatadine 0.2% eye drops in the treatment of vernal keratoconjunctivitis. Study Design: Prospective cross-sectional study. Place and Duration of Study: Eye Department Combined Military Hospital Quetta, from Feb to Jul 2019....
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doaj-fb9a8d47b3b7483183731ea49a9c696e2021-08-26T10:03:49ZengThe Army PressPakistan Armed Forces Medical Journal0030-96482411-88422021-02-01711343910.51253/pafmj.v71i1.32513251COMPARATIVE EVALUATION OF TACROLIMUS 0.03% OINTMENT VS OLOPATADINE 0.2% EYE DROPS IN THE TREATMENT OF VERNAL KERATOCONJUNCTIVITISHassan Sajjad Rathore0Shahzad Saeed1M. Ahsan Mukhtar2Umar Ijaz3Asad Habib4Iqra Ghaus5CMH QuettaCMH QuettaCMH QuettaCMH QuettaPNS Shifa KarachiCMH QuettaObjective: To compare the efficacy of tacrolimus 0.03% ointment to olopatadine 0.2% eye drops in the treatment of vernal keratoconjunctivitis. Study Design: Prospective cross-sectional study. Place and Duration of Study: Eye Department Combined Military Hospital Quetta, from Feb to Jul 2019. Methodology: A total of 69 patients with active vernal keratoconjunctivitis (VKC) were included in this study. Thirty six (52.17%) patients were randomized in tacrolimus group and 33 (47.83%) in olopatadine group B. Baseline values of the subjective symptom score (SSS) and the objective sign score (OSS) were noted. Patients were reviewed on weeks 2, 4, 8 and 12 and the scores at each visit were summed. These scores were used for comparison between groups. Results: At the start of the study, the mean subjective symptoms score and objective sign score of group A was 9.0 ± 2.04 and 3.93 ± 1.93 respectively, while that of group B was 8.88 ± 2.18 and 4.36 ± 1.90 respectively. At the end of 12-weeks, the mean subjective symptoms score and objective sign score of group A reduced to 0.11 ± 0.32 and 0.08 ± 0.28 respectively, while that of group B reduced to 1.70 ± 0.77 and 0.64 ± 0.55 respectively. Total improvement of scores (as a percentage of baselines) among tacrolimus group was 98.3% and olopatadine group was 83%. Conclusion: Although both 0.03% tacrolimus and 0.2% olopatadine were effective in improving the signs and symptoms of VKC, 0.03% tacrolimus was significantly superior.https://pafmj.org/index.php/PAFMJ/article/view/3251vernal keratoconjunctivitistacrolimusolopatadine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hassan Sajjad Rathore Shahzad Saeed M. Ahsan Mukhtar Umar Ijaz Asad Habib Iqra Ghaus |
spellingShingle |
Hassan Sajjad Rathore Shahzad Saeed M. Ahsan Mukhtar Umar Ijaz Asad Habib Iqra Ghaus COMPARATIVE EVALUATION OF TACROLIMUS 0.03% OINTMENT VS OLOPATADINE 0.2% EYE DROPS IN THE TREATMENT OF VERNAL KERATOCONJUNCTIVITIS Pakistan Armed Forces Medical Journal vernal keratoconjunctivitis tacrolimus olopatadine |
author_facet |
Hassan Sajjad Rathore Shahzad Saeed M. Ahsan Mukhtar Umar Ijaz Asad Habib Iqra Ghaus |
author_sort |
Hassan Sajjad Rathore |
title |
COMPARATIVE EVALUATION OF TACROLIMUS 0.03% OINTMENT VS OLOPATADINE 0.2% EYE DROPS IN THE TREATMENT OF VERNAL KERATOCONJUNCTIVITIS |
title_short |
COMPARATIVE EVALUATION OF TACROLIMUS 0.03% OINTMENT VS OLOPATADINE 0.2% EYE DROPS IN THE TREATMENT OF VERNAL KERATOCONJUNCTIVITIS |
title_full |
COMPARATIVE EVALUATION OF TACROLIMUS 0.03% OINTMENT VS OLOPATADINE 0.2% EYE DROPS IN THE TREATMENT OF VERNAL KERATOCONJUNCTIVITIS |
title_fullStr |
COMPARATIVE EVALUATION OF TACROLIMUS 0.03% OINTMENT VS OLOPATADINE 0.2% EYE DROPS IN THE TREATMENT OF VERNAL KERATOCONJUNCTIVITIS |
title_full_unstemmed |
COMPARATIVE EVALUATION OF TACROLIMUS 0.03% OINTMENT VS OLOPATADINE 0.2% EYE DROPS IN THE TREATMENT OF VERNAL KERATOCONJUNCTIVITIS |
title_sort |
comparative evaluation of tacrolimus 0.03% ointment vs olopatadine 0.2% eye drops in the treatment of vernal keratoconjunctivitis |
publisher |
The Army Press |
series |
Pakistan Armed Forces Medical Journal |
issn |
0030-9648 2411-8842 |
publishDate |
2021-02-01 |
description |
Objective: To compare the efficacy of tacrolimus 0.03% ointment to olopatadine 0.2% eye drops in the treatment of vernal keratoconjunctivitis.
Study Design: Prospective cross-sectional study.
Place and Duration of Study: Eye Department Combined Military Hospital Quetta, from Feb to Jul 2019.
Methodology: A total of 69 patients with active vernal keratoconjunctivitis (VKC) were included in this study.
Thirty six (52.17%) patients were randomized in tacrolimus group and 33 (47.83%) in olopatadine group B.
Baseline values of the subjective symptom score (SSS) and the objective sign score (OSS) were noted. Patients
were reviewed on weeks 2, 4, 8 and 12 and the scores at each visit were summed. These scores were used for
comparison between groups.
Results: At the start of the study, the mean subjective symptoms score and objective sign score of group A was 9.0 ± 2.04 and 3.93 ± 1.93 respectively, while that of group B was 8.88 ± 2.18 and 4.36 ± 1.90 respectively. At the end of 12-weeks, the mean subjective symptoms score and objective sign score of group A reduced to 0.11 ± 0.32 and 0.08 ± 0.28 respectively, while that of group B reduced to 1.70 ± 0.77 and 0.64 ± 0.55 respectively. Total improvement of scores (as a percentage of baselines) among tacrolimus group was 98.3% and olopatadine group was 83%.
Conclusion: Although both 0.03% tacrolimus and 0.2% olopatadine were effective in improving the signs and
symptoms of VKC, 0.03% tacrolimus was significantly superior. |
topic |
vernal keratoconjunctivitis tacrolimus olopatadine |
url |
https://pafmj.org/index.php/PAFMJ/article/view/3251 |
work_keys_str_mv |
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