Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis

Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis

Glycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenic mechanisms in motor neuronal death related to amyotrophic lateral...

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Main Authors: Seong-Ho Koh, Wonki Baek, Seung H. Kim
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Neurology Research International
Online Access:http://dx.doi.org/10.1155/2011/205761
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spelling doaj-fba636f28f0e4d67a97f9b3684c6d2d72020-11-25T02:46:56ZengHindawi LimitedNeurology Research International2090-18522090-18602011-01-01201110.1155/2011/205761205761Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral SclerosisSeong-Ho Koh0Wonki Baek1Seung H. Kim2Department of Neurology, College of Medicine Hanyang University, no. 17 Haengdang-Dong, Seongdong-Gu, Seoul 133-792, Republic of KoreaDepartment of Neurology, College of Medicine Hanyang University, no. 17 Haengdang-Dong, Seongdong-Gu, Seoul 133-792, Republic of KoreaDepartment of Neurology, College of Medicine Hanyang University, no. 17 Haengdang-Dong, Seongdong-Gu, Seoul 133-792, Republic of KoreaGlycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenic mechanisms in motor neuronal death related to amyotrophic lateral sclerosis (ALS). Therefore, the development of methods to control GSK-3β could be helpful in postponing the symptom progression of ALS. Here we discuss the known roles of GSK-3β in motor neuronal cell death in ALS and the possibility of employing GSK-3β modulators as a new therapeutic strategy.http://dx.doi.org/10.1155/2011/205761
collection DOAJ
language English
format Article
sources DOAJ
author Seong-Ho Koh
Wonki Baek
Seung H. Kim
spellingShingle Seong-Ho Koh
Wonki Baek
Seung H. Kim
Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis
Neurology Research International
author_facet Seong-Ho Koh
Wonki Baek
Seung H. Kim
author_sort Seong-Ho Koh
title Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis
title_short Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis
title_full Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis
title_fullStr Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis
title_full_unstemmed Brief Review of the Role of Glycogen Synthase Kinase-3β in Amyotrophic Lateral Sclerosis
title_sort brief review of the role of glycogen synthase kinase-3β in amyotrophic lateral sclerosis
publisher Hindawi Limited
series Neurology Research International
issn 2090-1852
2090-1860
publishDate 2011-01-01
description Glycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenic mechanisms in motor neuronal death related to amyotrophic lateral sclerosis (ALS). Therefore, the development of methods to control GSK-3β could be helpful in postponing the symptom progression of ALS. Here we discuss the known roles of GSK-3β in motor neuronal cell death in ALS and the possibility of employing GSK-3β modulators as a new therapeutic strategy.
url http://dx.doi.org/10.1155/2011/205761
work_keys_str_mv AT seonghokoh briefreviewoftheroleofglycogensynthasekinase3binamyotrophiclateralsclerosis
AT wonkibaek briefreviewoftheroleofglycogensynthasekinase3binamyotrophiclateralsclerosis
AT seunghkim briefreviewoftheroleofglycogensynthasekinase3binamyotrophiclateralsclerosis
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