Effect of the Hydrophilic-Hydrophobic Balance of Antigen-Loaded Peptide Nanofibers on Their Cellular Uptake, Cellular Toxicity, and Immune Stimulatory Properties

Effect of the Hydrophilic-Hydrophobic Balance of Antigen-Loaded Peptide Nanofibers on Their Cellular Uptake, Cellular Toxicity, and Immune Stimulatory Properties

Recently, nanofibers (NFs) formed from antigenic peptides conjugated to β-sheet-forming peptides have attracted much attention as a new generation of vaccines. However, studies describing how the hydrophilic-hydrophobic balance of NF components affects cellular interactions of NFs are limit...

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Bibliographic Details
Main Authors: Tomonori Waku, Saki Nishigaki, Yuichi Kitagawa, Sayaka Koeda, Kazufumi Kawabata, Shigeru Kunugi, Akio Kobori, Naoki Tanaka
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
peptide
nanofibers
poly(ethylene glycol)
antigen delivery
immune stimulation
Online Access:https://www.mdpi.com/1422-0067/20/15/3781

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