Predictors of the CD24/CD11b Biomarker among Healthy Subjects
The CD24 gene has raised considerable interest in tumor biology as a new prognostic factor and a biomarker for the early detection of cancer. There are currently no studies that assess predictors of CD24 in blood tests among healthy individuals. Our aims were (1) to evaluate predictors of the CD24/C...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-09-01
|
Series: | Journal of Personalized Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-4426/11/9/939 |
id |
doaj-fbbf2dd9c6d14ae9ba609e7e55c18698 |
---|---|
record_format |
Article |
spelling |
doaj-fbbf2dd9c6d14ae9ba609e7e55c186982021-09-26T00:32:23ZengMDPI AGJournal of Personalized Medicine2075-44262021-09-011193993910.3390/jpm11090939Predictors of the CD24/CD11b Biomarker among Healthy SubjectsShiran Shapira0Gal Aiger1Amitay Ohayon2Dina Kazanov3Fatin Mdah4Marina Ben Shimon5Mori Hay-Levy6Lian Banon7Ido Laskov8Jacob Mashiah9Shahar Lev-Ari10Nadir Arber11Integrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, IsraelIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, IsraelIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, IsraelIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, IsraelIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, IsraelIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, IsraelIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, IsraelTel Aviv Medical Center, The Gastroenterology Institute, Tel Aviv 6423906, IsraelGynecologic Oncology Unit, Tel Aviv Medical Center, Tel Aviv 6423906, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, IsraelIntegrated Cancer Prevention Center, Tel Aviv Medical Center, Tel Aviv 6423906, IsraelThe CD24 gene has raised considerable interest in tumor biology as a new prognostic factor and a biomarker for the early detection of cancer. There are currently no studies that assess predictors of CD24 in blood tests among healthy individuals. Our aims were (1) to evaluate predictors of the CD24/CD11b biomarker among healthy subjects and (2) to assess CD24/CD11b levels of participants with and without benign tumors. Our cohort included 1640 healthy subjects, aged 20–85, recruited at the Health Promotion and Integrated Cancer Prevention Center (ICPC) in the Tel Aviv Medical Center. Eligible subjects completed a detailed questionnaire on medical history and other epidemiologic information. CD24/CD11b expression in peripheral blood leukocytes (PBLs) obtained from blood samples of participants was analyzed by flow cytometry. Our results showed that the average levels of CD24/CD11b in healthy patients (22.8 ± 9.3) was statistically significant lower compared to subjects with benign cancers (26.1 ± 10.5, <i>p</i> < 0.001). Our multivariable analysis demonstrated that elevated levels of CRP (coefficient β: 1.98, <i>p</i> = 0.011) were significantly associated with high levels of CD24/CD11b expression among healthy participants. Other risk factors of cancer were not associated with elevated CD24 levels among healthy subjects. In conclusion, our findings may assist in further development and optimization of the CD24/CD11b biomarker to serve as a cancer screening test for early detection of cancer among the healthy population.https://www.mdpi.com/2075-4426/11/9/939CD24preventionscreening testbiomarker |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shiran Shapira Gal Aiger Amitay Ohayon Dina Kazanov Fatin Mdah Marina Ben Shimon Mori Hay-Levy Lian Banon Ido Laskov Jacob Mashiah Shahar Lev-Ari Nadir Arber |
spellingShingle |
Shiran Shapira Gal Aiger Amitay Ohayon Dina Kazanov Fatin Mdah Marina Ben Shimon Mori Hay-Levy Lian Banon Ido Laskov Jacob Mashiah Shahar Lev-Ari Nadir Arber Predictors of the CD24/CD11b Biomarker among Healthy Subjects Journal of Personalized Medicine CD24 prevention screening test biomarker |
author_facet |
Shiran Shapira Gal Aiger Amitay Ohayon Dina Kazanov Fatin Mdah Marina Ben Shimon Mori Hay-Levy Lian Banon Ido Laskov Jacob Mashiah Shahar Lev-Ari Nadir Arber |
author_sort |
Shiran Shapira |
title |
Predictors of the CD24/CD11b Biomarker among Healthy Subjects |
title_short |
Predictors of the CD24/CD11b Biomarker among Healthy Subjects |
title_full |
Predictors of the CD24/CD11b Biomarker among Healthy Subjects |
title_fullStr |
Predictors of the CD24/CD11b Biomarker among Healthy Subjects |
title_full_unstemmed |
Predictors of the CD24/CD11b Biomarker among Healthy Subjects |
title_sort |
predictors of the cd24/cd11b biomarker among healthy subjects |
publisher |
MDPI AG |
series |
Journal of Personalized Medicine |
issn |
2075-4426 |
publishDate |
2021-09-01 |
description |
The CD24 gene has raised considerable interest in tumor biology as a new prognostic factor and a biomarker for the early detection of cancer. There are currently no studies that assess predictors of CD24 in blood tests among healthy individuals. Our aims were (1) to evaluate predictors of the CD24/CD11b biomarker among healthy subjects and (2) to assess CD24/CD11b levels of participants with and without benign tumors. Our cohort included 1640 healthy subjects, aged 20–85, recruited at the Health Promotion and Integrated Cancer Prevention Center (ICPC) in the Tel Aviv Medical Center. Eligible subjects completed a detailed questionnaire on medical history and other epidemiologic information. CD24/CD11b expression in peripheral blood leukocytes (PBLs) obtained from blood samples of participants was analyzed by flow cytometry. Our results showed that the average levels of CD24/CD11b in healthy patients (22.8 ± 9.3) was statistically significant lower compared to subjects with benign cancers (26.1 ± 10.5, <i>p</i> < 0.001). Our multivariable analysis demonstrated that elevated levels of CRP (coefficient β: 1.98, <i>p</i> = 0.011) were significantly associated with high levels of CD24/CD11b expression among healthy participants. Other risk factors of cancer were not associated with elevated CD24 levels among healthy subjects. In conclusion, our findings may assist in further development and optimization of the CD24/CD11b biomarker to serve as a cancer screening test for early detection of cancer among the healthy population. |
topic |
CD24 prevention screening test biomarker |
url |
https://www.mdpi.com/2075-4426/11/9/939 |
work_keys_str_mv |
AT shiranshapira predictorsofthecd24cd11bbiomarkeramonghealthysubjects AT galaiger predictorsofthecd24cd11bbiomarkeramonghealthysubjects AT amitayohayon predictorsofthecd24cd11bbiomarkeramonghealthysubjects AT dinakazanov predictorsofthecd24cd11bbiomarkeramonghealthysubjects AT fatinmdah predictorsofthecd24cd11bbiomarkeramonghealthysubjects AT marinabenshimon predictorsofthecd24cd11bbiomarkeramonghealthysubjects AT morihaylevy predictorsofthecd24cd11bbiomarkeramonghealthysubjects AT lianbanon predictorsofthecd24cd11bbiomarkeramonghealthysubjects AT idolaskov predictorsofthecd24cd11bbiomarkeramonghealthysubjects AT jacobmashiah predictorsofthecd24cd11bbiomarkeramonghealthysubjects AT shaharlevari predictorsofthecd24cd11bbiomarkeramonghealthysubjects AT nadirarber predictorsofthecd24cd11bbiomarkeramonghealthysubjects |
_version_ |
1717365941764882432 |