Medical therapy for clinical benign prostatic hyperplasia: α1 Antagonists, 5α reductase inhibitors and their combination

• Main Authors: Cheuk Fan Shum, Weida Lau, Chang Peng Colin Teo
• Format: Article
• Language: English
• Published: Elsevier 2017-07-01
• Series: Asian Journal of Urology
• Online Access: http://www.sciencedirect.com/science/article/pii/S221438821730053X

Medical therapy for clinical benign prostatic hyperplasia (BPH) has advanced significantly in the last 2 decades. Many new α1 antagonists and 5α reductase inhibitors (5ARi) are now commercially available. The practicing urologist must decide on the most appropriate medication for his patients, taking into consideration various factors like efficacy, dosing regime, adverse effects, cost, patient's socioeconomic background, expectations, drug availability and his own clinical experience. The use of combination therapy added further to the complexity in clinical judgment when prescribing. We highlight some of the key points in prescribing α1 antagonists, 5ARi and their combination, based on our viewpoints and experience as urologists in an Asian clinical setting. Keywords: 5α Reductase inhibitors, Adrenergic α1 receptor antagonists, Drug therapy, Combination, Prostatic hyperplasia