NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

Nlrp3 inflammasome activation requires Nek7 recruitment to drive ASC speck formation. Here the authors show how Nlrp3 phosphorylation events control this Nek7 recruitment.

Bibliographic Details
Main Authors: Tingting Niu, Charlotte De Rosny, Séverine Chautard, Amaury Rey, Danish Patoli, Marine Groslambert, Camille Cosson, Brice Lagrange, Zhirong Zhang, Orane Visvikis, Sabine Hacot, Maggy Hologne, Olivier Walker, Jeimin Wong, Ping Wang, Roméo Ricci, Thomas Henry, Laurent Boyer, Virginie Petrilli, Bénédicte F. Py
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26142-w
id doaj-fbcf468393234f91b37ce912376f58ab
record_format Article
spelling doaj-fbcf468393234f91b37ce912376f58ab2021-10-10T11:45:10ZengNature Publishing GroupNature Communications2041-17232021-10-0112111510.1038/s41467-021-26142-wNLRP3 phosphorylation in its LRR domain critically regulates inflammasome assemblyTingting Niu0Charlotte De Rosny1Séverine Chautard2Amaury Rey3Danish Patoli4Marine Groslambert5Camille Cosson6Brice Lagrange7Zhirong Zhang8Orane Visvikis9Sabine Hacot10Maggy Hologne11Olivier Walker12Jeimin Wong13Ping Wang14Roméo Ricci15Thomas Henry16Laurent Boyer17Virginie Petrilli18Bénédicte F. Py19CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de LyonCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de LyonCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de LyonCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de LyonCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de LyonCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de LyonCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de LyonCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de LyonIGBMC, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, UMR7104, Inserm, U964, Université de StrasbourgUniversité Côte d’Azur, Inserm, C3MCRCL, Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Université de Lyon, Université Lyon 1, Centre Léon BérardInstitut des Sciences Analytiques (ISA), Univ Lyon, CNRS, CNRS UMR5280, Université Claude Bernard Lyon 1Institut des Sciences Analytiques (ISA), Univ Lyon, CNRS, CNRS UMR5280, Université Claude Bernard Lyon 1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal UniversityShanghai Tenth People’s Hospital of Tongji University, Tongji Cancer Center, School of Medicine, Tongji UniversityIGBMC, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, UMR7104, Inserm, U964, Université de StrasbourgCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de LyonUniversité Côte d’Azur, Inserm, C3MCRCL, Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR5286, Université de Lyon, Université Lyon 1, Centre Léon BérardCIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de LyonNlrp3 inflammasome activation requires Nek7 recruitment to drive ASC speck formation. Here the authors show how Nlrp3 phosphorylation events control this Nek7 recruitment.https://doi.org/10.1038/s41467-021-26142-w
collection DOAJ
language English
format Article
sources DOAJ
author Tingting Niu
Charlotte De Rosny
Séverine Chautard
Amaury Rey
Danish Patoli
Marine Groslambert
Camille Cosson
Brice Lagrange
Zhirong Zhang
Orane Visvikis
Sabine Hacot
Maggy Hologne
Olivier Walker
Jeimin Wong
Ping Wang
Roméo Ricci
Thomas Henry
Laurent Boyer
Virginie Petrilli
Bénédicte F. Py
spellingShingle Tingting Niu
Charlotte De Rosny
Séverine Chautard
Amaury Rey
Danish Patoli
Marine Groslambert
Camille Cosson
Brice Lagrange
Zhirong Zhang
Orane Visvikis
Sabine Hacot
Maggy Hologne
Olivier Walker
Jeimin Wong
Ping Wang
Roméo Ricci
Thomas Henry
Laurent Boyer
Virginie Petrilli
Bénédicte F. Py
NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
Nature Communications
author_facet Tingting Niu
Charlotte De Rosny
Séverine Chautard
Amaury Rey
Danish Patoli
Marine Groslambert
Camille Cosson
Brice Lagrange
Zhirong Zhang
Orane Visvikis
Sabine Hacot
Maggy Hologne
Olivier Walker
Jeimin Wong
Ping Wang
Roméo Ricci
Thomas Henry
Laurent Boyer
Virginie Petrilli
Bénédicte F. Py
author_sort Tingting Niu
title NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
title_short NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
title_full NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
title_fullStr NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
title_full_unstemmed NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
title_sort nlrp3 phosphorylation in its lrr domain critically regulates inflammasome assembly
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-10-01
description Nlrp3 inflammasome activation requires Nek7 recruitment to drive ASC speck formation. Here the authors show how Nlrp3 phosphorylation events control this Nek7 recruitment.
url https://doi.org/10.1038/s41467-021-26142-w
work_keys_str_mv AT tingtingniu nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT charlottederosny nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT severinechautard nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT amauryrey nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT danishpatoli nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT marinegroslambert nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT camillecosson nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT bricelagrange nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT zhirongzhang nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT oranevisvikis nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT sabinehacot nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT maggyhologne nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT olivierwalker nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT jeiminwong nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT pingwang nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT romeoricci nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT thomashenry nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT laurentboyer nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT virginiepetrilli nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
AT benedictefpy nlrp3phosphorylationinitslrrdomaincriticallyregulatesinflammasomeassembly
_version_ 1716829638592823296

Similar Items