Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice.
Histones package DNA and regulate epigenetic states. For the latter, probably the most important histone is H3. Mammals have three near-identical H3 isoforms: canonical H3.1 and H3.2, and the replication-independent variant H3.3. This variant can accumulate in slowly dividing somatic cells, replacin...
Main Authors: | Michelle C W Tang, Shelley A Jacobs, Deidre M Mattiske, Yu May Soh, Alison N Graham, An Tran, Shu Ly Lim, Damien F Hudson, Paul Kalitsis, Moira K O'Bryan, Lee H Wong, Jeffrey R Mann |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-02-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC4335506?pdf=render |
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