Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling.
Tropomyosin-related kinase B (TrkB) signaling is critical for promoting neuronal survival following brain damage. The present study investigated the effects and underlying mechanisms of TrkB activation by the TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) on traumatic brain injury (TBI). Mice subjected...
Main Authors: | Chun-Hu Wu, Tai-Ho Hung, Chien-Cheng Chen, Chia-Hua Ke, Chun-Yen Lee, Pei-Yi Wang, Szu-Fu Chen |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4240709?pdf=render |
Similar Items
-
7,8-Dihydroxyflavone, a TrkB Receptor Agonist, Protects Against Experimental Traumatic Brain Injury via Activation of the PI3K/Akt Signaling Pathway
by: Wu, Chunhu, et al.
Published: (2012) -
An Exploration of the Protective Effect of TrkB Activation by 7,8-Dihydroxyflavone in Experimental Intracerebral Hemorrhage
by: Chuang, Yen-Chieh, et al.
Published: (2014) -
Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins
by: Nitin Chitranshi, et al.
Published: (2015-09-01) -
The Effects of 7,8-Dihydroxyflavone on Hippocampal Neurogenesis Following Traumatic Brain Injury
by: Wurzelmann, Mary K
Published: (2016) -
7,8-Dihydroxyflavone Attenuates Alcohol-Related Behavior in Rat Models of Alcohol Consumption via TrkB in the Ventral Tegmental Area
by: Xin-Xin Li, et al.
Published: (2020-05-01)