Body fat in children with chronic kidney disease - A comparative study of bio-impedance analysis with dual energy X-ray absorptiometry
Introduction: Nutritional impairment in patients with chronic kidney disease (CKD) is due to decreased body stores of both protein and fat. We need a tool that can be used in clinics to determine and monitor fat composition with a special focus on normalizing fat measurements to height in these chil...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2021-01-01
|
Series: | Indian Journal of Nephrology |
Subjects: | |
Online Access: | http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=1;spage=39;epage=42;aulast=Iyengar |
id |
doaj-fbf872db3327451d9d03b494d24aeff7 |
---|---|
record_format |
Article |
spelling |
doaj-fbf872db3327451d9d03b494d24aeff72021-04-02T20:01:45ZengWolters Kluwer Medknow PublicationsIndian Journal of Nephrology0971-40651998-36622021-01-01311394210.4103/ijn.IJN_368_19Body fat in children with chronic kidney disease - A comparative study of bio-impedance analysis with dual energy X-ray absorptiometryArpana IyengarRebecca KuriyanAnura V KurpadAnil VasudevanIntroduction: Nutritional impairment in patients with chronic kidney disease (CKD) is due to decreased body stores of both protein and fat. We need a tool that can be used in clinics to determine and monitor fat composition with a special focus on normalizing fat measurements to height in these children. Bio-impedance analysis (BIA), a portable and simple tool, has been used to estimate body fat in children with CKD but needs validation against the reference tool dual energy X-ray absorptiometry (DXA). The purpose of the cross-sectional study was to estimate the prevalence of low body fat in children with stages 2-5 CKD (non-dialysis) and CKD 5D (dialysis), and to compare fat measures from two different methods namely BIA and DXA. Method: Children in stages 2–5 CKD (n = 19) and in CKD 5D (n = 14) were recruited for assessment of fat mass (FM, Kg) by BIA and DXA, from which percent body fat (BF %) and fat mass index (FMI, Kg/M2) were obtained. Low body fat was defined as <5th age and gender centile for BF% or FMI by DXA and BF% by BIA. Results: Low body fat was detected equally using BF% and FMI in 18% of children by DXA while only 12% were detected using BF% by BIA. In children with CKD2–5, a good degree of reliability was found with FMI measurements (ICC 0.76 CI [0.48,0.9]) and poor reliability in children with CKD 5D (ICC 0.58 CI [0.1,0.84]). BF% had poor to fair reliability in the children with CKD 2-5 and CKD 5D (ICC 0.64 [0.28,0.84] and 0.53 [0.02,0.82]), respectively. Comparing BF% and FMI obtained by BIA and DEXA, BIA overestimated BF% by 3.5% in comparison to DXA. Conclusion: In children with CKD, body fat is preserved in the majority. Among the two measures of fat, BF% estimated by BIA did not compare well with DXA while FMI measure was comparable with a lower bias. However, due to lack of reference values in Indian children for FMI obtained by BIA, BIA cannot be used to measure fat in this population.http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=1;spage=39;epage=42;aulast=Iyengarbiabody fatchildrenchronic kidney diseasedialysisdxafat mass |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Arpana Iyengar Rebecca Kuriyan Anura V Kurpad Anil Vasudevan |
spellingShingle |
Arpana Iyengar Rebecca Kuriyan Anura V Kurpad Anil Vasudevan Body fat in children with chronic kidney disease - A comparative study of bio-impedance analysis with dual energy X-ray absorptiometry Indian Journal of Nephrology bia body fat children chronic kidney disease dialysis dxa fat mass |
author_facet |
Arpana Iyengar Rebecca Kuriyan Anura V Kurpad Anil Vasudevan |
author_sort |
Arpana Iyengar |
title |
Body fat in children with chronic kidney disease - A comparative study of bio-impedance analysis with dual energy X-ray absorptiometry |
title_short |
Body fat in children with chronic kidney disease - A comparative study of bio-impedance analysis with dual energy X-ray absorptiometry |
title_full |
Body fat in children with chronic kidney disease - A comparative study of bio-impedance analysis with dual energy X-ray absorptiometry |
title_fullStr |
Body fat in children with chronic kidney disease - A comparative study of bio-impedance analysis with dual energy X-ray absorptiometry |
title_full_unstemmed |
Body fat in children with chronic kidney disease - A comparative study of bio-impedance analysis with dual energy X-ray absorptiometry |
title_sort |
body fat in children with chronic kidney disease - a comparative study of bio-impedance analysis with dual energy x-ray absorptiometry |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Nephrology |
issn |
0971-4065 1998-3662 |
publishDate |
2021-01-01 |
description |
Introduction: Nutritional impairment in patients with chronic kidney disease (CKD) is due to decreased body stores of both protein and fat. We need a tool that can be used in clinics to determine and monitor fat composition with a special focus on normalizing fat measurements to height in these children. Bio-impedance analysis (BIA), a portable and simple tool, has been used to estimate body fat in children with CKD but needs validation against the reference tool dual energy X-ray absorptiometry (DXA). The purpose of the cross-sectional study was to estimate the prevalence of low body fat in children with stages 2-5 CKD (non-dialysis) and CKD 5D (dialysis), and to compare fat measures from two different methods namely BIA and DXA. Method: Children in stages 2–5 CKD (n = 19) and in CKD 5D (n = 14) were recruited for assessment of fat mass (FM, Kg) by BIA and DXA, from which percent body fat (BF %) and fat mass index (FMI, Kg/M2) were obtained. Low body fat was defined as <5th age and gender centile for BF% or FMI by DXA and BF% by BIA. Results: Low body fat was detected equally using BF% and FMI in 18% of children by DXA while only 12% were detected using BF% by BIA. In children with CKD2–5, a good degree of reliability was found with FMI measurements (ICC 0.76 CI [0.48,0.9]) and poor reliability in children with CKD 5D (ICC 0.58 CI [0.1,0.84]). BF% had poor to fair reliability in the children with CKD 2-5 and CKD 5D (ICC 0.64 [0.28,0.84] and 0.53 [0.02,0.82]), respectively. Comparing BF% and FMI obtained by BIA and DEXA, BIA overestimated BF% by 3.5% in comparison to DXA. Conclusion: In children with CKD, body fat is preserved in the majority. Among the two measures of fat, BF% estimated by BIA did not compare well with DXA while FMI measure was comparable with a lower bias. However, due to lack of reference values in Indian children for FMI obtained by BIA, BIA cannot be used to measure fat in this population. |
topic |
bia body fat children chronic kidney disease dialysis dxa fat mass |
url |
http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=1;spage=39;epage=42;aulast=Iyengar |
work_keys_str_mv |
AT arpanaiyengar bodyfatinchildrenwithchronickidneydiseaseacomparativestudyofbioimpedanceanalysiswithdualenergyxrayabsorptiometry AT rebeccakuriyan bodyfatinchildrenwithchronickidneydiseaseacomparativestudyofbioimpedanceanalysiswithdualenergyxrayabsorptiometry AT anuravkurpad bodyfatinchildrenwithchronickidneydiseaseacomparativestudyofbioimpedanceanalysiswithdualenergyxrayabsorptiometry AT anilvasudevan bodyfatinchildrenwithchronickidneydiseaseacomparativestudyofbioimpedanceanalysiswithdualenergyxrayabsorptiometry |
_version_ |
1721548092285648896 |