Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases

Sphingolipids contribute to the regulation of cell and tissue homeostasis, and disorders of sphingolipid metabolism lead to diseases such as inflammation, stroke, diabetes, and cancer. Sphingolipid metabolic pathways involve an array of enzymes that reside in specific subcellular organelles, resulti...

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Bibliographic Details
Main Authors: Wataru Sakamoto, Daniel Canals, Silvia Salamone, Janet Allopenna, Christopher J. Clarke, Justin Snider, Lina M. Obeid, Yusuf A. Hannun
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520322835