Positive Charges in the Brace Region Facilitate the Membrane Disruption of MLKL-NTR in Necroptosis

Positive Charges in the Brace Region Facilitate the Membrane Disruption of MLKL-NTR in Necroptosis

Necroptosis is a type of programmed cell death executed through the plasma membrane disruption by mixed lineage kinase domain-like protein (MLKL). Previous studies have revealed that an N-terminal four-helix bundle domain (NBD) of MLKL is the executioner domain for the membrane permeabilization, whi...

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Bibliographic Details
Main Authors: Yaqing Yang, Encheng Xie, Lingyu Du, Yu Yang, Bin Wu, Liming Sun, Shuqing Wang, Bo OuYang
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
MLKL
brace helix
auto-inhibitory
MD simulation
Online Access:https://www.mdpi.com/1420-3049/26/17/5194

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