Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for status epilepticus: study protocol for a multicenter non-inferiority designed randomized control trial

Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for status epilepticus: study protocol for a multicenter non-inferiority designed randomized control trial

Abstract Background Status epilepticus (SE) is an emergency condition for which rapid and secured cessation is important. Phenytoin and fosphenytoin, the prodrug of phenytoin with less severe adverse effects, have been recommended as second-line treatments. However, fosphenytoin causes severe advers...

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Bibliographic Details
Main Authors: Kensuke Nakamura, Aiki Marushima, Yuji Takahashi, Akio Kimura, Masahiro Asami, Satoshi Egawa, Junya Kaneko, Yutaka Kondo, Chikara Yonekawa, Eisei Hoshiyama, Takeshi Yamada, Kazushi Maruo, Yoshiaki Inoue, IENE ECT with the LIFE study group
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Trials
Subjects:
Epilepsy
Fosphenytoin
Levetiracetam
Phenytoin
Seizure
Online Access:https://doi.org/10.1186/s13063-021-05269-7

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