Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth
Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results in increased survival of tumour-bearing animals.
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Nature Publishing Group
2017-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15080 |
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doaj-fc10d4b4ab8a4e3cb428bc0e733826492021-05-11T07:11:33ZengNature Publishing GroupNature Communications2041-17232017-06-018111710.1038/ncomms15080Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growthYu Shi0Yi-Fang Ping1Wenchao Zhou2Zhi-Cheng He3Cong Chen4Bai-Shi-Jiao Bian5Lin Zhang6Lu Chen7Xun Lan8Xian-Chao Zhang9Kai Zhou10Qing Liu11Hua Long12Ti-Wei Fu13Xiao-Ning Zhang14Mian-Fu Cao15Zhi Huang16Xiaoguang Fang17Xiuxing Wang18Hua Feng19Xiao-Hong Yao20Shi-Cang Yu21You-Hong Cui22Xia Zhang23Jeremy N Rich24Shideng Bao25Xiu-Wu Bian26Institute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland ClinicInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityDepartment of Ophthalmology, Southwest Hospital, The Third Military Medical UniversityDepartment of Neurology, Xijing Hospital, The Fourth Military Medical UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityDepartment of Genetics, Stanford UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Neurosurgery, Southwest Hospital, The Third Military Medical UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland ClinicInstitute of Pathology and Southwest Cancer Centre, Southwest Hospital, The Third Military Medical UniversityTumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results in increased survival of tumour-bearing animals.https://doi.org/10.1038/ncomms15080 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yu Shi Yi-Fang Ping Wenchao Zhou Zhi-Cheng He Cong Chen Bai-Shi-Jiao Bian Lin Zhang Lu Chen Xun Lan Xian-Chao Zhang Kai Zhou Qing Liu Hua Long Ti-Wei Fu Xiao-Ning Zhang Mian-Fu Cao Zhi Huang Xiaoguang Fang Xiuxing Wang Hua Feng Xiao-Hong Yao Shi-Cang Yu You-Hong Cui Xia Zhang Jeremy N Rich Shideng Bao Xiu-Wu Bian |
| spellingShingle |
Yu Shi Yi-Fang Ping Wenchao Zhou Zhi-Cheng He Cong Chen Bai-Shi-Jiao Bian Lin Zhang Lu Chen Xun Lan Xian-Chao Zhang Kai Zhou Qing Liu Hua Long Ti-Wei Fu Xiao-Ning Zhang Mian-Fu Cao Zhi Huang Xiaoguang Fang Xiuxing Wang Hua Feng Xiao-Hong Yao Shi-Cang Yu You-Hong Cui Xia Zhang Jeremy N Rich Shideng Bao Xiu-Wu Bian Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth Nature Communications |
| author_facet |
Yu Shi Yi-Fang Ping Wenchao Zhou Zhi-Cheng He Cong Chen Bai-Shi-Jiao Bian Lin Zhang Lu Chen Xun Lan Xian-Chao Zhang Kai Zhou Qing Liu Hua Long Ti-Wei Fu Xiao-Ning Zhang Mian-Fu Cao Zhi Huang Xiaoguang Fang Xiuxing Wang Hua Feng Xiao-Hong Yao Shi-Cang Yu You-Hong Cui Xia Zhang Jeremy N Rich Shideng Bao Xiu-Wu Bian |
| author_sort |
Yu Shi |
| title |
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth |
| title_short |
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth |
| title_full |
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth |
| title_fullStr |
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth |
| title_full_unstemmed |
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth |
| title_sort |
tumour-associated macrophages secrete pleiotrophin to promote ptprz1 signalling in glioblastoma stem cells for tumour growth |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-06-01 |
| description |
Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results in increased survival of tumour-bearing animals. |
| url |
https://doi.org/10.1038/ncomms15080 |
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