Assessment of the Preventive Effect of Pilocarpine on Radiotherapy-Induced Xerostomia in Patients with Head and Neck Cancers
Introduction Xerostomia is one of side-effects of radiotherapy for head and neck cancers. No definitive method has been proposed for the treatment of this condition. However, pilocarpine is considered effective for the management of chronic xerostomia. The purpose of the present study was to assess...
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Mashhad University of Medical Sciences
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doaj-fc118d4099534f1aa41c3f195be1e21e2020-11-24T22:14:47ZengMashhad University of Medical SciencesIranian Journal of Medical Physics2345-36722345-36722016-04-0112423524110.22038/ijmp.2016.68366836Assessment of the Preventive Effect of Pilocarpine on Radiotherapy-Induced Xerostomia in Patients with Head and Neck CancersMohammad Hasan Akhavan Karbasi0Hassan Zarghani1Seyed Ali Akhavan2Nastaran Donyadide3Pejman Shamshiry4Department of Oral Medicine, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Radiology, Birjand University of Medical Science, Birjand, IranRadiotherapist, Ramezanzadeh Radiotherapy Center, Yazd, IranDepartment of Oral Medicine, School of Dentistry, Sharekord University of Medical Sciences, Sharekord, IranSchool of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, IranIntroduction Xerostomia is one of side-effects of radiotherapy for head and neck cancers. No definitive method has been proposed for the treatment of this condition. However, pilocarpine is considered effective for the management of chronic xerostomia. The purpose of the present study was to assess the preventive effect of pilocarpine. Materials and Methods This study was performed on 34 patients with head and neck cancers, undergoing radiation therapy (5000 cGy). The patients were randomly divided into two groups. The case group was administered 16 drops of pilocarpine (2%) eye drops per day, while the control group received normal saline; the treatment plan continued for four weeks. Unstimulated whole saliva flow rate was measured at four stages: two weeks before radiotherapy (baseline), the first day of radiotherapy, and two and four weeks after the initiation of radiotherapy. Results At baseline and the first day of radiotherapy, no significant differences were observed in the amount of saliva between the case and control groups (PConclusion According to the findings, pilocarpine was found to be effective for the prevention of xerostomia. Moreover, it could restrain the decline in the amount of saliva and reduce the rate of xerostomia.http://ijmp.mums.ac.ir/article_6836_8c47e323345186f22f8d9cbde0d2e71c.pdfHead and Neck NeoplasmsPilocarpineRadiotherapysalivaXerostomia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Hasan Akhavan Karbasi Hassan Zarghani Seyed Ali Akhavan Nastaran Donyadide Pejman Shamshiry |
spellingShingle |
Mohammad Hasan Akhavan Karbasi Hassan Zarghani Seyed Ali Akhavan Nastaran Donyadide Pejman Shamshiry Assessment of the Preventive Effect of Pilocarpine on Radiotherapy-Induced Xerostomia in Patients with Head and Neck Cancers Iranian Journal of Medical Physics Head and Neck Neoplasms Pilocarpine Radiotherapy saliva Xerostomia |
author_facet |
Mohammad Hasan Akhavan Karbasi Hassan Zarghani Seyed Ali Akhavan Nastaran Donyadide Pejman Shamshiry |
author_sort |
Mohammad Hasan Akhavan Karbasi |
title |
Assessment of the Preventive Effect of Pilocarpine on Radiotherapy-Induced Xerostomia in Patients with Head and Neck Cancers |
title_short |
Assessment of the Preventive Effect of Pilocarpine on Radiotherapy-Induced Xerostomia in Patients with Head and Neck Cancers |
title_full |
Assessment of the Preventive Effect of Pilocarpine on Radiotherapy-Induced Xerostomia in Patients with Head and Neck Cancers |
title_fullStr |
Assessment of the Preventive Effect of Pilocarpine on Radiotherapy-Induced Xerostomia in Patients with Head and Neck Cancers |
title_full_unstemmed |
Assessment of the Preventive Effect of Pilocarpine on Radiotherapy-Induced Xerostomia in Patients with Head and Neck Cancers |
title_sort |
assessment of the preventive effect of pilocarpine on radiotherapy-induced xerostomia in patients with head and neck cancers |
publisher |
Mashhad University of Medical Sciences |
series |
Iranian Journal of Medical Physics |
issn |
2345-3672 2345-3672 |
publishDate |
2016-04-01 |
description |
Introduction Xerostomia is one of side-effects of radiotherapy for head and neck cancers. No definitive method has been proposed for the treatment of this condition. However, pilocarpine is considered effective for the management of chronic xerostomia. The purpose of the present study was to assess the preventive effect of pilocarpine. Materials and Methods This study was performed on 34 patients with head and neck cancers, undergoing radiation therapy (5000 cGy). The patients were randomly divided into two groups. The case group was administered 16 drops of pilocarpine (2%) eye drops per day, while the control group received normal saline; the treatment plan continued for four weeks. Unstimulated whole saliva flow rate was measured at four stages: two weeks before radiotherapy (baseline), the first day of radiotherapy, and two and four weeks after the initiation of radiotherapy. Results At baseline and the first day of radiotherapy, no significant differences were observed in the amount of saliva between the case and control groups (PConclusion According to the findings, pilocarpine was found to be effective for the prevention of xerostomia. Moreover, it could restrain the decline in the amount of saliva and reduce the rate of xerostomia. |
topic |
Head and Neck Neoplasms Pilocarpine Radiotherapy saliva Xerostomia |
url |
http://ijmp.mums.ac.ir/article_6836_8c47e323345186f22f8d9cbde0d2e71c.pdf |
work_keys_str_mv |
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