Uncover miRNA-Disease Association by Exploiting Global Network Similarity.
Identification of miRNA-disease association is a fundamental challenge in human health clinic. However, the known miRNA-disease associations are rare and experimental verification methods are expensive and time-consuming. Therefore, there is a strong incentive to develop computational methods. In th...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5132253?pdf=render |
id |
doaj-fc18295a51454dffba45f388aee43110 |
---|---|
record_format |
Article |
spelling |
doaj-fc18295a51454dffba45f388aee431102020-11-25T01:49:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016650910.1371/journal.pone.0166509Uncover miRNA-Disease Association by Exploiting Global Network Similarity.Min ChenXingguo LuBo LiaoZejun LiLijun CaiChanglong GuIdentification of miRNA-disease association is a fundamental challenge in human health clinic. However, the known miRNA-disease associations are rare and experimental verification methods are expensive and time-consuming. Therefore, there is a strong incentive to develop computational methods. In this paper, we calculate the similarity score for each miRNAs pair by integrating miRNA functional similarity and miRNA family information. We use the disease phenotype similarity data to construct the disease similarity network. Then we introduce a new miRNA-disease association prediction method (NETwork Group Similarity, NetGS) to explore the global network similarity, capturing the relationship between the disease and other diseases, the similarity between the potential disease-related miRNA and other miRNAs. Finally based on the consistency of diffusion profiles we get the miRNA-disease association scores. NetGS is tested by the leave-one-out cross validation and achieves an AUC value of 0.8450, which improves the prediction accuracy. NetGS can also be applied to solve the new miRNA-disease association and obtain reliable accuracy. Moreover, we use NetGS to predict new causing miRNAs of three cancers including breast cancer, lung cancer and Hepatocellular cancer. And the top predictions have been confirmed in the online databases. The encouraging results indicate that NetGS might play an essential role for future scientific research.http://europepmc.org/articles/PMC5132253?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Min Chen Xingguo Lu Bo Liao Zejun Li Lijun Cai Changlong Gu |
spellingShingle |
Min Chen Xingguo Lu Bo Liao Zejun Li Lijun Cai Changlong Gu Uncover miRNA-Disease Association by Exploiting Global Network Similarity. PLoS ONE |
author_facet |
Min Chen Xingguo Lu Bo Liao Zejun Li Lijun Cai Changlong Gu |
author_sort |
Min Chen |
title |
Uncover miRNA-Disease Association by Exploiting Global Network Similarity. |
title_short |
Uncover miRNA-Disease Association by Exploiting Global Network Similarity. |
title_full |
Uncover miRNA-Disease Association by Exploiting Global Network Similarity. |
title_fullStr |
Uncover miRNA-Disease Association by Exploiting Global Network Similarity. |
title_full_unstemmed |
Uncover miRNA-Disease Association by Exploiting Global Network Similarity. |
title_sort |
uncover mirna-disease association by exploiting global network similarity. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
Identification of miRNA-disease association is a fundamental challenge in human health clinic. However, the known miRNA-disease associations are rare and experimental verification methods are expensive and time-consuming. Therefore, there is a strong incentive to develop computational methods. In this paper, we calculate the similarity score for each miRNAs pair by integrating miRNA functional similarity and miRNA family information. We use the disease phenotype similarity data to construct the disease similarity network. Then we introduce a new miRNA-disease association prediction method (NETwork Group Similarity, NetGS) to explore the global network similarity, capturing the relationship between the disease and other diseases, the similarity between the potential disease-related miRNA and other miRNAs. Finally based on the consistency of diffusion profiles we get the miRNA-disease association scores. NetGS is tested by the leave-one-out cross validation and achieves an AUC value of 0.8450, which improves the prediction accuracy. NetGS can also be applied to solve the new miRNA-disease association and obtain reliable accuracy. Moreover, we use NetGS to predict new causing miRNAs of three cancers including breast cancer, lung cancer and Hepatocellular cancer. And the top predictions have been confirmed in the online databases. The encouraging results indicate that NetGS might play an essential role for future scientific research. |
url |
http://europepmc.org/articles/PMC5132253?pdf=render |
work_keys_str_mv |
AT minchen uncovermirnadiseaseassociationbyexploitingglobalnetworksimilarity AT xingguolu uncovermirnadiseaseassociationbyexploitingglobalnetworksimilarity AT boliao uncovermirnadiseaseassociationbyexploitingglobalnetworksimilarity AT zejunli uncovermirnadiseaseassociationbyexploitingglobalnetworksimilarity AT lijuncai uncovermirnadiseaseassociationbyexploitingglobalnetworksimilarity AT changlonggu uncovermirnadiseaseassociationbyexploitingglobalnetworksimilarity |
_version_ |
1725005196510101504 |