Mitochondrial Uncoupler Prodrug of 2,4-Dinitrophenol, MP201, Prevents Neuronal Damage and Preserves Vision in Experimental Optic Neuritis
The ability of novel mitochondrial uncoupler prodrug of 2,4-dinitrophenol (DNP), MP201, to prevent neuronal damage and preserve visual function in an experimental autoimmune encephalomyelitis (EAE) model of optic neuritis was evaluated. Optic nerve inflammation, demyelination, and axonal loss are pr...
Main Authors: | Reas S. Khan, Kimberly Dine, John G. Geisler, Kenneth S. Shindler |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2017-01-01
|
Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2017/7180632 |
Similar Items
-
2,4 Dinitrophenol as Medicine
by: John G. Geisler
Published: (2019-03-01) -
Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis
by: Manmeet Singh, et al.
Published: (2018-09-01) -
Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis
by: Reas S. Khan, et al.
Published: (2019-08-01) -
2-Aminopyridinium 2,4-dinitrophenolate
by: S. Reena Devi, et al.
Published: (2016-09-01) -
Mitochondrial Uncoupling Proteins (UCP1-UCP3) and Adenine Nucleotide Translocase (ANT1) Enhance the Protonophoric Action of 2,4-Dinitrophenol in Mitochondria and Planar Bilayer Membranes
by: Kristina Žuna, et al.
Published: (2021-08-01)