Peran matriks metaloproteinase-8 pada cairan krevikuler gingiva selama pergerakan gigi ortodontik
Orthodontic treatment usually involves tooth movement. The orthodontic force as an extrinsic mechanical stimulus, evokes a biologic cellular response in the periodontal supporting ligament. At early stage, it causes inflammation of periodontal tissue which is followed by the release of cytokines, T...
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| Format: | Article |
| Language: | English |
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Hasanuddin University
2010-04-01
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| Series: | Journal of Dentomaxillofacial Science |
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| Online Access: | http://jdmfs.org/index.php/jdmfs/article/view/232 |
| Summary: | Orthodontic treatment usually involves tooth movement. The orthodontic force as an
extrinsic mechanical stimulus, evokes a biologic cellular response in the periodontal
supporting ligament. At early stage, it causes inflammation of periodontal tissue
which is followed by the release of cytokines, T cell, B cell, and then MMP enzyme.
MMP-8 (collagenase 2) is a member of matrixin subfamily plays an important role in
periodontal ligament remodeling. It has capability to maintain the cellular structure,
integrity, activity, and function of extracellular matrix of periodontal tissue. The main
component of extracellular matrix is tissue protein, i.e. collagen, fibronectin, and
glicosaminoglycan. During orthodontic tooth movement, collagen degradation occurs
in extracellular matrix of periodontal tissue and alveolar bone. As a result, it enables
the release of cells from extracellular environment, for example osteoblast moves to
apposition and osteoclast to resorption sites that enable the tooth movement. The
expression and level of MMP-8 can be assessed in the gingival crevicular fluid. The
aim of this review is to describe the role of MMP-8 in orthodontic tooth movement. |
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| ISSN: | 2503-0817 2503-0825 |