Arterial Stiffness Assessment Using the Arteriograph in Patients with Moderate–Severe OSA and Metabolic Syndrome—A Pilot Study
Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect early modifications induced by continuous positive...
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doaj-fc2570d2f4804a5696f5eb1a3754d0df2021-09-26T00:28:46ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-01104238423810.3390/jcm10184238Arterial Stiffness Assessment Using the Arteriograph in Patients with Moderate–Severe OSA and Metabolic Syndrome—A Pilot StudyIoana Mădălina Zota0Cristian Stătescu1Radu Andy Sascău2Mihai Roca3Larisa Anghel4Ovidiu Mitu5Cristina Mihaela Ghiciuc6Daniela Boisteanu7Razvan Anghel8Sebastian Romica Cozma9Lucia Corina Dima-Cozma10Florin Mitu11Department of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, RomaniaDepartment of Morpho-Functional Sciences (II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, RomaniaDepartment of Medical Specialties (III), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, RomaniaDepartment of Surgery (II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Iași, 700115 Iasi, RomaniaBackground: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect early modifications induced by continuous positive airway therapy (CPAP) in reversing this detrimental vascular remodeling. Arterial stiffness is increasingly acknowledged as a major cardiovascular risk factor and a marker of subclinical hypertension-mediated organ damage. The aim of this pilot study was to evaluate the arterial stiffness changes in patients with moderate–severe OSA and MS after short-term CPAP use. Methods: We performed a prospective study that included patients with moderate–severe OSA and MS who had not undergone previous CPAP therapy. All subjects underwent clinical examination and arterial stiffness assessment using the oscillometric technique with Arteriograph (TensioMed, Budapest, Hungary) detection before and after 8-week CPAP therapy. Results: 39 patients with moderate–severe OSA were included. Eight weeks of CPAP therapy significantly improved central systolic blood pressure (Δ = −11.4 mmHg, <i>p</i> = 0.009), aortic pulse wave velocity (aoPWV: Δ = −0.66 m/s, <i>p</i> = 0.03), and aortic augmentation index (aoAix: Δ = −8.25%, <i>p</i> = 0.01) only in patients who used the device for a minimum of 4 h/night (<i>n</i> = 20). Conclusions: Arterial stiffness was improved only among CPAP adherent patients and could be detected using the Arteriograph (TensioMed, Budapest, Hungary), which involves a noninvasive procedure that is easy to implement for the clinical evaluation of arterial stiffness.https://www.mdpi.com/2077-0383/10/18/4238arterial stiffnessArteriographobstructive sleep apnea (OSA)continuous positive airway pressure (CPAP)metabolic syndrome (MS)adherence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ioana Mădălina Zota Cristian Stătescu Radu Andy Sascău Mihai Roca Larisa Anghel Ovidiu Mitu Cristina Mihaela Ghiciuc Daniela Boisteanu Razvan Anghel Sebastian Romica Cozma Lucia Corina Dima-Cozma Florin Mitu |
spellingShingle |
Ioana Mădălina Zota Cristian Stătescu Radu Andy Sascău Mihai Roca Larisa Anghel Ovidiu Mitu Cristina Mihaela Ghiciuc Daniela Boisteanu Razvan Anghel Sebastian Romica Cozma Lucia Corina Dima-Cozma Florin Mitu Arterial Stiffness Assessment Using the Arteriograph in Patients with Moderate–Severe OSA and Metabolic Syndrome—A Pilot Study Journal of Clinical Medicine arterial stiffness Arteriograph obstructive sleep apnea (OSA) continuous positive airway pressure (CPAP) metabolic syndrome (MS) adherence |
author_facet |
Ioana Mădălina Zota Cristian Stătescu Radu Andy Sascău Mihai Roca Larisa Anghel Ovidiu Mitu Cristina Mihaela Ghiciuc Daniela Boisteanu Razvan Anghel Sebastian Romica Cozma Lucia Corina Dima-Cozma Florin Mitu |
author_sort |
Ioana Mădălina Zota |
title |
Arterial Stiffness Assessment Using the Arteriograph in Patients with Moderate–Severe OSA and Metabolic Syndrome—A Pilot Study |
title_short |
Arterial Stiffness Assessment Using the Arteriograph in Patients with Moderate–Severe OSA and Metabolic Syndrome—A Pilot Study |
title_full |
Arterial Stiffness Assessment Using the Arteriograph in Patients with Moderate–Severe OSA and Metabolic Syndrome—A Pilot Study |
title_fullStr |
Arterial Stiffness Assessment Using the Arteriograph in Patients with Moderate–Severe OSA and Metabolic Syndrome—A Pilot Study |
title_full_unstemmed |
Arterial Stiffness Assessment Using the Arteriograph in Patients with Moderate–Severe OSA and Metabolic Syndrome—A Pilot Study |
title_sort |
arterial stiffness assessment using the arteriograph in patients with moderate–severe osa and metabolic syndrome—a pilot study |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-09-01 |
description |
Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect early modifications induced by continuous positive airway therapy (CPAP) in reversing this detrimental vascular remodeling. Arterial stiffness is increasingly acknowledged as a major cardiovascular risk factor and a marker of subclinical hypertension-mediated organ damage. The aim of this pilot study was to evaluate the arterial stiffness changes in patients with moderate–severe OSA and MS after short-term CPAP use. Methods: We performed a prospective study that included patients with moderate–severe OSA and MS who had not undergone previous CPAP therapy. All subjects underwent clinical examination and arterial stiffness assessment using the oscillometric technique with Arteriograph (TensioMed, Budapest, Hungary) detection before and after 8-week CPAP therapy. Results: 39 patients with moderate–severe OSA were included. Eight weeks of CPAP therapy significantly improved central systolic blood pressure (Δ = −11.4 mmHg, <i>p</i> = 0.009), aortic pulse wave velocity (aoPWV: Δ = −0.66 m/s, <i>p</i> = 0.03), and aortic augmentation index (aoAix: Δ = −8.25%, <i>p</i> = 0.01) only in patients who used the device for a minimum of 4 h/night (<i>n</i> = 20). Conclusions: Arterial stiffness was improved only among CPAP adherent patients and could be detected using the Arteriograph (TensioMed, Budapest, Hungary), which involves a noninvasive procedure that is easy to implement for the clinical evaluation of arterial stiffness. |
topic |
arterial stiffness Arteriograph obstructive sleep apnea (OSA) continuous positive airway pressure (CPAP) metabolic syndrome (MS) adherence |
url |
https://www.mdpi.com/2077-0383/10/18/4238 |
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