Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach
The design of new drugs with better physiochemical properties, adequate absorption, distribution, metabolism, and excretion, effective pharmacologic potency and lacking toxicity remains is a challenge. Inflammation is the initial trigger of several different diseases, such as Alzheimer’s disease, as...
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Online Access: | http://www.mdpi.com/1424-8247/4/11/1450/ |
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doaj-fc25e607f1b840f0b91704722282a9f82020-11-25T03:57:43ZengMDPI AGPharmaceuticals1424-82472011-10-014111450147410.3390/ph4111450Anti-Inflammatory Drug Design Using a Molecular Hybridization ApproachJean Leandro dos SantosMan Chin ChungEdnir Oliveira VizioliPriscila Longhin BosquesiThais Regina Ferreira MeloThe design of new drugs with better physiochemical properties, adequate absorption, distribution, metabolism, and excretion, effective pharmacologic potency and lacking toxicity remains is a challenge. Inflammation is the initial trigger of several different diseases, such as Alzheimer’s disease, asthma, atherosclerosis, colitis, rheumatoid arthritis, depression, cancer; and disorders such as obesity and sexual dysfunction. Although inflammation is not the direct cause of these disorders, inflammatory processes often increase related pain and suffering. New anti-inflammatory drugs developed using molecular hybridization techniques to obtain multiple-ligand drugs can act at one or multiple targets, allowing for synergic action and minimizing toxicity. This work is a review of new anti-inflammatory drugs developed using the molecular modification approach.http://www.mdpi.com/1424-8247/4/11/1450/anti-inflammatoryhybridizationmultiple-ligandsmutual prodrug |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jean Leandro dos Santos Man Chin Chung Ednir Oliveira Vizioli Priscila Longhin Bosquesi Thais Regina Ferreira Melo |
spellingShingle |
Jean Leandro dos Santos Man Chin Chung Ednir Oliveira Vizioli Priscila Longhin Bosquesi Thais Regina Ferreira Melo Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach Pharmaceuticals anti-inflammatory hybridization multiple-ligands mutual prodrug |
author_facet |
Jean Leandro dos Santos Man Chin Chung Ednir Oliveira Vizioli Priscila Longhin Bosquesi Thais Regina Ferreira Melo |
author_sort |
Jean Leandro dos Santos |
title |
Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach |
title_short |
Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach |
title_full |
Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach |
title_fullStr |
Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach |
title_full_unstemmed |
Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach |
title_sort |
anti-inflammatory drug design using a molecular hybridization approach |
publisher |
MDPI AG |
series |
Pharmaceuticals |
issn |
1424-8247 |
publishDate |
2011-10-01 |
description |
The design of new drugs with better physiochemical properties, adequate absorption, distribution, metabolism, and excretion, effective pharmacologic potency and lacking toxicity remains is a challenge. Inflammation is the initial trigger of several different diseases, such as Alzheimer’s disease, asthma, atherosclerosis, colitis, rheumatoid arthritis, depression, cancer; and disorders such as obesity and sexual dysfunction. Although inflammation is not the direct cause of these disorders, inflammatory processes often increase related pain and suffering. New anti-inflammatory drugs developed using molecular hybridization techniques to obtain multiple-ligand drugs can act at one or multiple targets, allowing for synergic action and minimizing toxicity. This work is a review of new anti-inflammatory drugs developed using the molecular modification approach. |
topic |
anti-inflammatory hybridization multiple-ligands mutual prodrug |
url |
http://www.mdpi.com/1424-8247/4/11/1450/ |
work_keys_str_mv |
AT jeanleandrodossantos antiinflammatorydrugdesignusingamolecularhybridizationapproach AT manchinchung antiinflammatorydrugdesignusingamolecularhybridizationapproach AT edniroliveiravizioli antiinflammatorydrugdesignusingamolecularhybridizationapproach AT priscilalonghinbosquesi antiinflammatorydrugdesignusingamolecularhybridizationapproach AT thaisreginaferreiramelo antiinflammatorydrugdesignusingamolecularhybridizationapproach |
_version_ |
1724459050807066624 |