Combination therapy with SGLT2 inhibitors for diabetic kidney disease
Sodium–glucose cotransporter 2 (SGLT2) inhibitors are a novel class of oral antihyperglycemic agents developed in recent years. They could block most glucose reabsorption in renal proximal tubules, thereby exerting glucose lowering effects through glycosuric ways. The renal and cardiovascular protec...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-07-01
|
Series: | Biomedicine & Pharmacotherapy |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222030384X |
id |
doaj-fc2fc9c7dbc34ec29fb0abd447751a12 |
---|---|
record_format |
Article |
spelling |
doaj-fc2fc9c7dbc34ec29fb0abd447751a122021-05-20T07:41:49ZengElsevierBiomedicine & Pharmacotherapy0753-33222020-07-01127110192Combination therapy with SGLT2 inhibitors for diabetic kidney diseaseYuwen Cai0Xin Liu1Gaosi Xu2Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Jiangxi, China; Grade 2016, The Second Clinical Medical College of Nanchang University, Jiangxi, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Nanchang University, Jiangxi, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Nanchang University, Jiangxi, China; Corresponding author at: Department of Nephrology, The Second Affiliated Hospital of Nanchang University, No. 1, Minde Road, Donghu District, Nanchang 330006, China.Sodium–glucose cotransporter 2 (SGLT2) inhibitors are a novel class of oral antihyperglycemic agents developed in recent years. They could block most glucose reabsorption in renal proximal tubules, thereby exerting glucose lowering effects through glycosuric ways. The renal and cardiovascular protection effects of SGLT2 inhibitors have also been demonstrated both in preclinical studies and clinical trials. However, SGLT2 inhibitors alone could induce an increase in endogenous/hepatic glucose production as well as in fasting plasma glucose levels; a sharp decrease of blood glucose concentration induced by SGLT2 inhibitors could also promote the secretion of counter-regulatory hormones such as glucagon, which has been reported to be associated with the occurrence of glycemic ketoacidosis. Therefore, coadministration of SGLT2 inhibitors and other antihyperglycemic agents should be considered when the therapeutic effect of SGLT2 inhibitors alone was unsatisfactory.http://www.sciencedirect.com/science/article/pii/S075333222030384XACEI/ARBsDiabetic kidney diseaseDPP-4 inhibitorsGLP-1 receptor agonistsSGLT-2 inhibitors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuwen Cai Xin Liu Gaosi Xu |
spellingShingle |
Yuwen Cai Xin Liu Gaosi Xu Combination therapy with SGLT2 inhibitors for diabetic kidney disease Biomedicine & Pharmacotherapy ACEI/ARBs Diabetic kidney disease DPP-4 inhibitors GLP-1 receptor agonists SGLT-2 inhibitors |
author_facet |
Yuwen Cai Xin Liu Gaosi Xu |
author_sort |
Yuwen Cai |
title |
Combination therapy with SGLT2 inhibitors for diabetic kidney disease |
title_short |
Combination therapy with SGLT2 inhibitors for diabetic kidney disease |
title_full |
Combination therapy with SGLT2 inhibitors for diabetic kidney disease |
title_fullStr |
Combination therapy with SGLT2 inhibitors for diabetic kidney disease |
title_full_unstemmed |
Combination therapy with SGLT2 inhibitors for diabetic kidney disease |
title_sort |
combination therapy with sglt2 inhibitors for diabetic kidney disease |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2020-07-01 |
description |
Sodium–glucose cotransporter 2 (SGLT2) inhibitors are a novel class of oral antihyperglycemic agents developed in recent years. They could block most glucose reabsorption in renal proximal tubules, thereby exerting glucose lowering effects through glycosuric ways. The renal and cardiovascular protection effects of SGLT2 inhibitors have also been demonstrated both in preclinical studies and clinical trials. However, SGLT2 inhibitors alone could induce an increase in endogenous/hepatic glucose production as well as in fasting plasma glucose levels; a sharp decrease of blood glucose concentration induced by SGLT2 inhibitors could also promote the secretion of counter-regulatory hormones such as glucagon, which has been reported to be associated with the occurrence of glycemic ketoacidosis. Therefore, coadministration of SGLT2 inhibitors and other antihyperglycemic agents should be considered when the therapeutic effect of SGLT2 inhibitors alone was unsatisfactory. |
topic |
ACEI/ARBs Diabetic kidney disease DPP-4 inhibitors GLP-1 receptor agonists SGLT-2 inhibitors |
url |
http://www.sciencedirect.com/science/article/pii/S075333222030384X |
work_keys_str_mv |
AT yuwencai combinationtherapywithsglt2inhibitorsfordiabetickidneydisease AT xinliu combinationtherapywithsglt2inhibitorsfordiabetickidneydisease AT gaosixu combinationtherapywithsglt2inhibitorsfordiabetickidneydisease |
_version_ |
1721435062117859328 |