Impact of frailty on hospital adverse outcomes in elderly admitted with acute coronary syndrome
Background: Frailty represents a complex clinical syndrome of decreased physiological reserve and increased vulnerability to stressors. Little is known regarding interaction between frailty status and outcomes in patients with acute coronary syndrome. Our study aims to assess the prevalence of frail...
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Sociedade Galega de Medicina Interna
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doaj-fc32559d18ca4dc6ad54759ffe5c2ce52020-11-25T01:29:51ZengSociedade Galega de Medicina InternaGalicia Clínica0304-48661989-39222020-01-01VolNum4710.22546/55/17411741Impact of frailty on hospital adverse outcomes in elderly admitted with acute coronary syndromeFernando Montenegro Sá0Fátima Saraiva1Francisco Soares2José Leite3João Morais4Centro Hospitalar de LeiriaCentro Hospitalar de LeiriaCentro Hospitalar de LeiriaCentro Hospitalar de LeiriaCentro Hospitalar de LeiriaBackground: Frailty represents a complex clinical syndrome of decreased physiological reserve and increased vulnerability to stressors. Little is known regarding interaction between frailty status and outcomes in patients with acute coronary syndrome. Our study aims to assess the prevalence of frailty and its impact on in-hospital adverse outcomes of patients aged ≥ 75 years admitted for acute coronary syndromes. Methods: In this retrospective, single centre, observational study were included patients aged ≥ 75 years admitted for acute coronary syndromes between January 2011 and December 2015. Frailty was assessed using the Fried criteria. The primary endpoint was all-cause in-hospital mortality. Secondary endpoints included the occurrence of re-infarction, stroke and major bleeding. Results: Of the 502 patients included, 126 were classified as frail. These patients were older (mean age 78±5.5 vs. 76.2±5.5 years; p=0.02), more often male (68.3%) and had a higher risk profile according to GRACE (151.4±18.8 vs. 132.1±16.8; p<0.0001), TIMI (4.3±1 vs. 3.1±1; p<0.001) and CRUSADE (34.6±9.4 vs. 25.8±9.5; p<0.001) scores at admission. All-cause in-hospital mortality was significantly more frequent in frail patients (11.9% vs. 5.6%; p<0.001), as well as re-infarction (7.4% vs. 4.8%; p<0.001), stroke (8.7% vs. 0.5%; p=0.002) and major bleeding (7.9% vs. 1.6%; p=0.002). On multivariate analysis, frailty remained independently associated with the primary endpoint (OR 5.63, [2.05-10.35]; p<0.001). Conclusion: Frailty, identified by Fried criteria, is frequent in elderly patients with acute coronary syndromes, and it is an independent prognostic predictor for in-hospital mortality.https://galiciaclinica.info/publicacion.asp?f=1741sindrome coronario agudoancianofragilidadprognostico |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fernando Montenegro Sá Fátima Saraiva Francisco Soares José Leite João Morais |
spellingShingle |
Fernando Montenegro Sá Fátima Saraiva Francisco Soares José Leite João Morais Impact of frailty on hospital adverse outcomes in elderly admitted with acute coronary syndrome Galicia Clínica sindrome coronario agudo anciano fragilidad prognostico |
author_facet |
Fernando Montenegro Sá Fátima Saraiva Francisco Soares José Leite João Morais |
author_sort |
Fernando Montenegro Sá |
title |
Impact of frailty on hospital adverse outcomes in elderly admitted with acute coronary syndrome |
title_short |
Impact of frailty on hospital adverse outcomes in elderly admitted with acute coronary syndrome |
title_full |
Impact of frailty on hospital adverse outcomes in elderly admitted with acute coronary syndrome |
title_fullStr |
Impact of frailty on hospital adverse outcomes in elderly admitted with acute coronary syndrome |
title_full_unstemmed |
Impact of frailty on hospital adverse outcomes in elderly admitted with acute coronary syndrome |
title_sort |
impact of frailty on hospital adverse outcomes in elderly admitted with acute coronary syndrome |
publisher |
Sociedade Galega de Medicina Interna |
series |
Galicia Clínica |
issn |
0304-4866 1989-3922 |
publishDate |
2020-01-01 |
description |
Background: Frailty represents a complex clinical syndrome of decreased physiological reserve and increased vulnerability to stressors. Little is known regarding interaction between frailty status and outcomes in patients with acute coronary syndrome. Our study aims to assess the prevalence of frailty and its impact on in-hospital adverse outcomes of patients aged ≥ 75 years admitted for acute coronary syndromes.
Methods: In this retrospective, single centre, observational study were included patients aged ≥ 75 years admitted for acute coronary syndromes between January 2011 and December 2015. Frailty was assessed using the Fried criteria. The primary endpoint was all-cause in-hospital mortality. Secondary endpoints included the occurrence of re-infarction, stroke and major bleeding.
Results: Of the 502 patients included, 126 were classified as frail. These patients were older (mean age 78±5.5 vs. 76.2±5.5 years; p=0.02), more often male (68.3%) and had a higher risk profile according to GRACE (151.4±18.8 vs. 132.1±16.8; p<0.0001), TIMI (4.3±1 vs. 3.1±1; p<0.001) and CRUSADE (34.6±9.4 vs. 25.8±9.5; p<0.001) scores at admission. All-cause in-hospital mortality was significantly more frequent in frail patients (11.9% vs. 5.6%; p<0.001), as well as re-infarction (7.4% vs. 4.8%; p<0.001), stroke (8.7% vs. 0.5%; p=0.002) and major bleeding (7.9% vs. 1.6%; p=0.002). On multivariate analysis, frailty remained independently associated with the primary endpoint (OR 5.63, [2.05-10.35]; p<0.001).
Conclusion: Frailty, identified by Fried criteria, is frequent in elderly patients with acute coronary syndromes, and it is an independent prognostic predictor for in-hospital mortality. |
topic |
sindrome coronario agudo anciano fragilidad prognostico |
url |
https://galiciaclinica.info/publicacion.asp?f=1741 |
work_keys_str_mv |
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