Application of a Photocatalyst as an Inactivator of Bovine Coronavirus
Bovine coronavirus (BCoV), a major causative pathogen of bovine enteric and respiratory diseases and a zoonotic pathogen transmissible between animals and humans, has led to severe economic losses in numerous countries. BCoV belongs to the genus <i>Betacoronavirus</i>, which is a model o...
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doaj-fc38cb73fd6d4f8c890b553516a9f2582020-12-01T00:03:10ZengMDPI AGViruses1999-49152020-11-01121372137210.3390/v12121372Application of a Photocatalyst as an Inactivator of Bovine CoronavirusNobuki Yoshizawa0Ryoko Ishihara1Daisuke Omiya2Midori Ishitsuka3Shouichirou Hirano4Tohru Suzuki5Division of Pathology and Pathophysiology, Hokkaido Research Station, National Institute of Animal Health, NARO, Sapporo, Hokkaido 062-0045, JapanDivision of Pathology and Pathophysiology, Hokkaido Research Station, National Institute of Animal Health, NARO, Sapporo, Hokkaido 062-0045, JapanBio and Healthcare Business Division, Tsukuba Technical Center, Wako Filter Technology Co., Ltd., Bando, Ibaraki 306-0616, JapanBio and Healthcare Business Division, Tsukuba Technical Center, Wako Filter Technology Co., Ltd., Bando, Ibaraki 306-0616, JapanBio and Healthcare Business Division, Tsukuba Technical Center, Wako Filter Technology Co., Ltd., Bando, Ibaraki 306-0616, JapanDivision of Pathology and Pathophysiology, Hokkaido Research Station, National Institute of Animal Health, NARO, Sapporo, Hokkaido 062-0045, JapanBovine coronavirus (BCoV), a major causative pathogen of bovine enteric and respiratory diseases and a zoonotic pathogen transmissible between animals and humans, has led to severe economic losses in numerous countries. BCoV belongs to the genus <i>Betacoronavirus</i>, which is a model of a pathogen that is threatening human health and includes severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2, and Middle East respiratory syndrome coronavirus. This study aimed to determine whether photocatalytic material effectively reduces CoVs in the environment. Using the film adhesion method of photocatalytic materials, we assessed its antiviral activity and the effect of visible light irradiation according to methods defined by the International Organization for Standardization. Consequently, photocatalytic material was found to have antiviral activity, reducing the viral loads by 2.7 log TCID<sub>50</sub> (tissue culture infective dose 50)/0.1 mL (500 lux), 2.8 log TCID<sub>50</sub>/0.1 mL (1000 lux), and 2.4 log TCID<sub>50</sub>/0.1 mL (3000 lux). Hence, this photocatalytic material might be applicable not only to reducing CoVs in the cattle breeding environment but also perhaps in other indoor spaces, such as offices and hospital rooms. To our knowledge, this study is the first to evaluate the antiviral activity of a photocatalytic material against CoV.https://www.mdpi.com/1999-4915/12/12/1372bovine coronavirusphotocatalystantiviral activityvisible light irradiationinactivator |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nobuki Yoshizawa Ryoko Ishihara Daisuke Omiya Midori Ishitsuka Shouichirou Hirano Tohru Suzuki |
spellingShingle |
Nobuki Yoshizawa Ryoko Ishihara Daisuke Omiya Midori Ishitsuka Shouichirou Hirano Tohru Suzuki Application of a Photocatalyst as an Inactivator of Bovine Coronavirus Viruses bovine coronavirus photocatalyst antiviral activity visible light irradiation inactivator |
author_facet |
Nobuki Yoshizawa Ryoko Ishihara Daisuke Omiya Midori Ishitsuka Shouichirou Hirano Tohru Suzuki |
author_sort |
Nobuki Yoshizawa |
title |
Application of a Photocatalyst as an Inactivator of Bovine Coronavirus |
title_short |
Application of a Photocatalyst as an Inactivator of Bovine Coronavirus |
title_full |
Application of a Photocatalyst as an Inactivator of Bovine Coronavirus |
title_fullStr |
Application of a Photocatalyst as an Inactivator of Bovine Coronavirus |
title_full_unstemmed |
Application of a Photocatalyst as an Inactivator of Bovine Coronavirus |
title_sort |
application of a photocatalyst as an inactivator of bovine coronavirus |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2020-11-01 |
description |
Bovine coronavirus (BCoV), a major causative pathogen of bovine enteric and respiratory diseases and a zoonotic pathogen transmissible between animals and humans, has led to severe economic losses in numerous countries. BCoV belongs to the genus <i>Betacoronavirus</i>, which is a model of a pathogen that is threatening human health and includes severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2, and Middle East respiratory syndrome coronavirus. This study aimed to determine whether photocatalytic material effectively reduces CoVs in the environment. Using the film adhesion method of photocatalytic materials, we assessed its antiviral activity and the effect of visible light irradiation according to methods defined by the International Organization for Standardization. Consequently, photocatalytic material was found to have antiviral activity, reducing the viral loads by 2.7 log TCID<sub>50</sub> (tissue culture infective dose 50)/0.1 mL (500 lux), 2.8 log TCID<sub>50</sub>/0.1 mL (1000 lux), and 2.4 log TCID<sub>50</sub>/0.1 mL (3000 lux). Hence, this photocatalytic material might be applicable not only to reducing CoVs in the cattle breeding environment but also perhaps in other indoor spaces, such as offices and hospital rooms. To our knowledge, this study is the first to evaluate the antiviral activity of a photocatalytic material against CoV. |
topic |
bovine coronavirus photocatalyst antiviral activity visible light irradiation inactivator |
url |
https://www.mdpi.com/1999-4915/12/12/1372 |
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