Antinociceptive Effects of Sodium Channel-Blocking Agents on Acute Pain in Mice
The effects of various sodium channel blocking agents on acute thermal and mechanical nociception, as assessed using the plantar and tail pressure tests, respectively, were compared with the effects of morphine. The drugs used were mexiletine, lidocaine, carbamazepine, phenytoin, eperisone, tolperis...
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doaj-fc48d69ff1064b6cbd37eab0f797d4752020-11-24T21:49:50ZengElsevierJournal of Pharmacological Sciences1347-86132004-01-01952181188Antinociceptive Effects of Sodium Channel-Blocking Agents on Acute Pain in MiceAkiko Sakaue0Motoko Honda1Mitsuo Tanabe2Hideki Ono3Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, JapanLaboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, JapanLaboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, JapanLaboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan; Corresponding author. FAX: +81-52-836-3676 E-mail: hiono@phar.nagoya-cu.ac.jpThe effects of various sodium channel blocking agents on acute thermal and mechanical nociception, as assessed using the plantar and tail pressure tests, respectively, were compared with the effects of morphine. The drugs used were mexiletine, lidocaine, carbamazepine, phenytoin, eperisone, tolperisone, and zonisamide. The sodium channel blocking agents exhibited a rather preferential elevation of the threshold for thermal nociception. By contrast, morphine produced similar analgesic effects on thermal and mechanical nociception. In the sciatic nerve isolated from mice, mexiletine, lidocaine, eperisone, and tolperisone impaired the propagation of low frequency action potentials (evoked at 0.2 Hz). Carbamazepine, phenytoin, and zonisamide generated a more frequency-dependent local anesthetic action with their obvious effects on higher frequency action potentials (evoked at 5 and/or 10 Hz). Our results show that sodium channel blocking agents have a preferential antinociceptive action against thermal stimulation that is likely to be attributed to their local anesthetic action. Keywords:: sodium channel blocker, plantar test, tail pressure test, local anesthetic actionhttp://www.sciencedirect.com/science/article/pii/S1347861319324351 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Akiko Sakaue Motoko Honda Mitsuo Tanabe Hideki Ono |
spellingShingle |
Akiko Sakaue Motoko Honda Mitsuo Tanabe Hideki Ono Antinociceptive Effects of Sodium Channel-Blocking Agents on Acute Pain in Mice Journal of Pharmacological Sciences |
author_facet |
Akiko Sakaue Motoko Honda Mitsuo Tanabe Hideki Ono |
author_sort |
Akiko Sakaue |
title |
Antinociceptive Effects of Sodium Channel-Blocking Agents on Acute Pain in Mice |
title_short |
Antinociceptive Effects of Sodium Channel-Blocking Agents on Acute Pain in Mice |
title_full |
Antinociceptive Effects of Sodium Channel-Blocking Agents on Acute Pain in Mice |
title_fullStr |
Antinociceptive Effects of Sodium Channel-Blocking Agents on Acute Pain in Mice |
title_full_unstemmed |
Antinociceptive Effects of Sodium Channel-Blocking Agents on Acute Pain in Mice |
title_sort |
antinociceptive effects of sodium channel-blocking agents on acute pain in mice |
publisher |
Elsevier |
series |
Journal of Pharmacological Sciences |
issn |
1347-8613 |
publishDate |
2004-01-01 |
description |
The effects of various sodium channel blocking agents on acute thermal and mechanical nociception, as assessed using the plantar and tail pressure tests, respectively, were compared with the effects of morphine. The drugs used were mexiletine, lidocaine, carbamazepine, phenytoin, eperisone, tolperisone, and zonisamide. The sodium channel blocking agents exhibited a rather preferential elevation of the threshold for thermal nociception. By contrast, morphine produced similar analgesic effects on thermal and mechanical nociception. In the sciatic nerve isolated from mice, mexiletine, lidocaine, eperisone, and tolperisone impaired the propagation of low frequency action potentials (evoked at 0.2 Hz). Carbamazepine, phenytoin, and zonisamide generated a more frequency-dependent local anesthetic action with their obvious effects on higher frequency action potentials (evoked at 5 and/or 10 Hz). Our results show that sodium channel blocking agents have a preferential antinociceptive action against thermal stimulation that is likely to be attributed to their local anesthetic action. Keywords:: sodium channel blocker, plantar test, tail pressure test, local anesthetic action |
url |
http://www.sciencedirect.com/science/article/pii/S1347861319324351 |
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