Circulating miR-122-5p and miR-375 as Potential Biomarkers for Bone Mass Recovery after Parathyroidectomy in Patients with Primary Hyperparathyroidism: A Proof-of-Concept Study
Primary hyperparathyroidism (PHPT) is the leading cause of secondary osteoporosis. Although bone mineral density (BMD) tends to recover after parathyroidectomy in PHPT patients, the degree of recovery varies. Circulating microRNAs (miRNAs) profiles are known to be correlated with osteoporosis and fr...
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doaj-fc4e03cd57d34402a7f20c3a158af0fc2021-09-25T23:59:32ZengMDPI AGDiagnostics2075-44182021-09-01111704170410.3390/diagnostics11091704Circulating miR-122-5p and miR-375 as Potential Biomarkers for Bone Mass Recovery after Parathyroidectomy in Patients with Primary Hyperparathyroidism: A Proof-of-Concept StudySeunghyun Lee0Namki Hong1Yongnyun Kim2Sunyoung Park3Kyoung-Jin Kim4Jongju Jeong5Hyo-Il Jung6Yumie Rhee7Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, KoreaYonsei University Health System, Seoul 03722, KoreaDepartment of Mechanical Engineering, Yonsei University, Seodaemun-gu, Seoul 03722, KoreaDepartment of Internal Medicine, Korea University College of Medicine, Seoul 02841, KoreaDepartment of Surgery, Thyroid Cancer Clinic, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Mechanical Engineering, Yonsei University, Seodaemun-gu, Seoul 03722, KoreaDepartment of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, KoreaPrimary hyperparathyroidism (PHPT) is the leading cause of secondary osteoporosis. Although bone mineral density (BMD) tends to recover after parathyroidectomy in PHPT patients, the degree of recovery varies. Circulating microRNAs (miRNAs) profiles are known to be correlated with osteoporosis and fracture. We aimed to investigate whether osteoporotic fracture-related miRNAs are associated with postoperative BMD recovery in PHPT. Here, 16 previously identified osteoporotic fracture-related miRNAs were selected. We analyzed the association between the preoperative level of each miRNA and total hip (TH) BMD change. All 12 patients (among the 18 patients enrolled) were cured of PHPT after parathyroidectomy as parathyroid hormone (PTH) and calcium levels were restored to the normal range. Preoperative miR-19b-3p, miR-122-5p, and miR-375 showed a negative association with the percent changes in TH BMD from baseline. The association remained robust for miR-122-5p and miR-375 even after adjusting for sex, age, PTH, and procollagen type 1 N-terminal propeptide levels in a multivariable model. In conclusion, preoperative circulating miR-122-5p and miR-375 levels were negatively associated with TH BMD changes after parathyroidectomy in PHPT patients. miRNAs have the potential to serve as predictive biomarkers of treatment response in PHPT patients, which merits further investigation.https://www.mdpi.com/2075-4418/11/9/1704microRNAprimary hyperparathyroidismbone mineral density |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Seunghyun Lee Namki Hong Yongnyun Kim Sunyoung Park Kyoung-Jin Kim Jongju Jeong Hyo-Il Jung Yumie Rhee |
spellingShingle |
Seunghyun Lee Namki Hong Yongnyun Kim Sunyoung Park Kyoung-Jin Kim Jongju Jeong Hyo-Il Jung Yumie Rhee Circulating miR-122-5p and miR-375 as Potential Biomarkers for Bone Mass Recovery after Parathyroidectomy in Patients with Primary Hyperparathyroidism: A Proof-of-Concept Study Diagnostics microRNA primary hyperparathyroidism bone mineral density |
author_facet |
Seunghyun Lee Namki Hong Yongnyun Kim Sunyoung Park Kyoung-Jin Kim Jongju Jeong Hyo-Il Jung Yumie Rhee |
author_sort |
Seunghyun Lee |
title |
Circulating miR-122-5p and miR-375 as Potential Biomarkers for Bone Mass Recovery after Parathyroidectomy in Patients with Primary Hyperparathyroidism: A Proof-of-Concept Study |
title_short |
Circulating miR-122-5p and miR-375 as Potential Biomarkers for Bone Mass Recovery after Parathyroidectomy in Patients with Primary Hyperparathyroidism: A Proof-of-Concept Study |
title_full |
Circulating miR-122-5p and miR-375 as Potential Biomarkers for Bone Mass Recovery after Parathyroidectomy in Patients with Primary Hyperparathyroidism: A Proof-of-Concept Study |
title_fullStr |
Circulating miR-122-5p and miR-375 as Potential Biomarkers for Bone Mass Recovery after Parathyroidectomy in Patients with Primary Hyperparathyroidism: A Proof-of-Concept Study |
title_full_unstemmed |
Circulating miR-122-5p and miR-375 as Potential Biomarkers for Bone Mass Recovery after Parathyroidectomy in Patients with Primary Hyperparathyroidism: A Proof-of-Concept Study |
title_sort |
circulating mir-122-5p and mir-375 as potential biomarkers for bone mass recovery after parathyroidectomy in patients with primary hyperparathyroidism: a proof-of-concept study |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2021-09-01 |
description |
Primary hyperparathyroidism (PHPT) is the leading cause of secondary osteoporosis. Although bone mineral density (BMD) tends to recover after parathyroidectomy in PHPT patients, the degree of recovery varies. Circulating microRNAs (miRNAs) profiles are known to be correlated with osteoporosis and fracture. We aimed to investigate whether osteoporotic fracture-related miRNAs are associated with postoperative BMD recovery in PHPT. Here, 16 previously identified osteoporotic fracture-related miRNAs were selected. We analyzed the association between the preoperative level of each miRNA and total hip (TH) BMD change. All 12 patients (among the 18 patients enrolled) were cured of PHPT after parathyroidectomy as parathyroid hormone (PTH) and calcium levels were restored to the normal range. Preoperative miR-19b-3p, miR-122-5p, and miR-375 showed a negative association with the percent changes in TH BMD from baseline. The association remained robust for miR-122-5p and miR-375 even after adjusting for sex, age, PTH, and procollagen type 1 N-terminal propeptide levels in a multivariable model. In conclusion, preoperative circulating miR-122-5p and miR-375 levels were negatively associated with TH BMD changes after parathyroidectomy in PHPT patients. miRNAs have the potential to serve as predictive biomarkers of treatment response in PHPT patients, which merits further investigation. |
topic |
microRNA primary hyperparathyroidism bone mineral density |
url |
https://www.mdpi.com/2075-4418/11/9/1704 |
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