The Effect of Gabapentin Plus Celecoxib on Pain and Associated Complications After Laminectomy
Introduction: Prevention and treatment of postoperative pain is a major challenge in postoperative care and well-being of the surgical patient. The multimodal analgesic method has been recommended as an alternative treatment for the management of postoperative pain. Aim: To assess the comparati...
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doaj-fc52bbef5bf247c7812950390e0e22f02020-11-25T03:14:59ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-03-01103UC04UC0810.7860/JCDR/2016/17923.7346The Effect of Gabapentin Plus Celecoxib on Pain and Associated Complications After LaminectomyAminolah Vasigh0Molouk Jaafarpour1Javaher khajavikhan2Ali Khani3Anaesthesiologist, Department of Anaesthesiology, Medicine Faculty, Ilam University of Medical Science, Ilam, IR-Iran.Faculty, Department of Midwifery, Nursing & Midwifery Faculty, Ilam University of Medical Science, Ilam, IR-Iran.Anaesthesiologist, Department of Anaesthesiology, Medicine Faculty, Ilam University of Medical Science, Ilam, IR-Iran.Faculty, Department of Nursing, Nursing & Midwifery Faculty, Ilam University of Medical Science, Ilam, IR-Iran.Introduction: Prevention and treatment of postoperative pain is a major challenge in postoperative care and well-being of the surgical patient. The multimodal analgesic method has been recommended as an alternative treatment for the management of postoperative pain. Aim: To assess the comparative effect of gabapentin versus gabapentin plus celecoxib on pain and associated complications after laminectomy. Materials and Methods: In this randomized double- blind clinical trial, 114 patients scheduled for elective laminectomy received gabapentin (n=38, 900 mg daily), gabapentin plus celecoxib (n=38, 200 mg celecoxib plus 300mg gabapentin twice a day), and placebo (n=38, capsule containing starch). Visual Analog Scale (VAS) was used to determine the severity of pain. Complications after surgery, anxiety scores before surgery and patient’s satisfaction 24 hour after surgery were recorded. Results: The mean pain sevenity score and morphine consumption in the gabapentin plus celecoxib group were less compared to the placebo and gabapentin group respectively at various intervals (p < 0.001). The mean anxiety score, shivering, nausea, vomiting and pruritus in the gabapentin group were significantly lower compared to the placebo and gabapentin plus celecoxib groups respectively (p < 0.001, p < 0.05). The frequencies of drowsiness (42.1%) in the gabapentin group were significantly high compared to the placebo and gabapentin plus celecoxib group respectively (p <0.001, p< 0.05). In the gabapentin plus celecoxib group patient satisfaction was significantly higher compared to the placebo and gabapentin group (p< 0.05). Conclusion: Combination of 300 mg gabapentin plus 200 mg celecoxib twice a day is a good alternative in multimodal analgesia, effective in pain control with lesser side effects seen with gabapentin alone. https://jcdr.net/articles/PDF/7346/17923_CE[Ra]_F(Sh)_PF1(BMAK)_PFA(NC_AK)_PF2(PAG).pdfanalgesiacelecoxibgabapentinlumbar spine surgerymultimodal therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aminolah Vasigh Molouk Jaafarpour Javaher khajavikhan Ali Khani |
spellingShingle |
Aminolah Vasigh Molouk Jaafarpour Javaher khajavikhan Ali Khani The Effect of Gabapentin Plus Celecoxib on Pain and Associated Complications After Laminectomy Journal of Clinical and Diagnostic Research analgesia celecoxib gabapentin lumbar spine surgery multimodal therapy |
author_facet |
Aminolah Vasigh Molouk Jaafarpour Javaher khajavikhan Ali Khani |
author_sort |
Aminolah Vasigh |
title |
The Effect of Gabapentin Plus Celecoxib on Pain and Associated Complications After Laminectomy |
title_short |
The Effect of Gabapentin Plus Celecoxib on Pain and Associated Complications After Laminectomy |
title_full |
The Effect of Gabapentin Plus Celecoxib on Pain and Associated Complications After Laminectomy |
title_fullStr |
The Effect of Gabapentin Plus Celecoxib on Pain and Associated Complications After Laminectomy |
title_full_unstemmed |
The Effect of Gabapentin Plus Celecoxib on Pain and Associated Complications After Laminectomy |
title_sort |
effect of gabapentin plus celecoxib on pain and associated complications after laminectomy |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2016-03-01 |
description |
Introduction: Prevention and treatment of postoperative pain
is a major challenge in postoperative care and well-being of the
surgical patient. The multimodal analgesic method has been
recommended as an alternative treatment for the management
of postoperative pain.
Aim: To assess the comparative effect of gabapentin versus
gabapentin plus celecoxib on pain and associated complications
after laminectomy.
Materials and Methods: In this randomized double- blind
clinical trial, 114 patients scheduled for elective laminectomy
received gabapentin (n=38, 900 mg daily), gabapentin plus
celecoxib (n=38, 200 mg celecoxib plus 300mg gabapentin
twice a day), and placebo (n=38, capsule containing starch).
Visual Analog Scale (VAS) was used to determine the severity of
pain. Complications after surgery, anxiety scores before surgery
and patient’s satisfaction 24 hour after surgery were recorded.
Results: The mean pain sevenity score and morphine
consumption in the gabapentin plus celecoxib group were less
compared to the placebo and gabapentin group respectively at
various intervals (p < 0.001). The mean anxiety score, shivering,
nausea, vomiting and pruritus in the gabapentin group were
significantly lower compared to the placebo and gabapentin
plus celecoxib groups respectively (p < 0.001, p < 0.05). The
frequencies of drowsiness (42.1%) in the gabapentin group
were significantly high compared to the placebo and gabapentin
plus celecoxib group respectively (p <0.001, p< 0.05). In the
gabapentin plus celecoxib group patient satisfaction was
significantly higher compared to the placebo and gabapentin
group (p< 0.05).
Conclusion: Combination of 300 mg gabapentin plus 200
mg celecoxib twice a day is a good alternative in multimodal
analgesia, effective in pain control with lesser side effects seen
with gabapentin alone. |
topic |
analgesia celecoxib gabapentin lumbar spine surgery multimodal therapy |
url |
https://jcdr.net/articles/PDF/7346/17923_CE[Ra]_F(Sh)_PF1(BMAK)_PFA(NC_AK)_PF2(PAG).pdf |
work_keys_str_mv |
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