Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction

Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development. A simple and efficient method for C-9 alkylation and arylation of quinine derivatives was reported. Series quinine derivatives...

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Main Authors: Teni Ernawati, Minarti Minarti, Puspa Dewi Narrij Lotulung
Format: Article
Language:English
Published: University of Brawijaya 2020-04-01
Series:Journal of Pure and Applied Chemistry Research
Subjects:
Online Access:https://jpacr.ub.ac.id/index.php/jpacr/article/view/505/pdf
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spelling doaj-fc54e426ed7346be810d49cb7090b0e52021-04-15T16:01:31ZengUniversity of BrawijayaJournal of Pure and Applied Chemistry Research2302-46902302-46902020-04-01913239Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification ReactionTeni Ernawati 0Minarti Minarti1Puspa Dewi Narrij Lotulung2Medicinal Chemistry Research Group Research Center for Chemistry (RCC) Indonesian Institute of Sciences (LIPI)Medicinal Chemistry Research Group Research Center for Chemistry (RCC) Indonesian Institute of Sciences (LIPI)Medicinal Chemistry Research Group Research Center for Chemistry (RCC) Indonesian Institute of Sciences (LIPI)Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development. A simple and efficient method for C-9 alkylation and arylation of quinine derivatives was reported. Series quinine derivatives were synthesized through the esterification of the hydroxyl group of quinine. The reaction with various alkyl and aryl carbonyl chloride resulted in the series of ester quinine derivatives. The structure of quinine derivatives was characterized by IR, melting point, UV, 1H NMR, 13C NMR, LCMS.https://jpacr.ub.ac.id/index.php/jpacr/article/view/505/pdfmodificationsynthesisquinine derivativesester
collection DOAJ
language English
format Article
sources DOAJ
author Teni Ernawati
Minarti Minarti
Puspa Dewi Narrij Lotulung
spellingShingle Teni Ernawati
Minarti Minarti
Puspa Dewi Narrij Lotulung
Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction
Journal of Pure and Applied Chemistry Research
modification
synthesis
quinine derivatives
ester
author_facet Teni Ernawati
Minarti Minarti
Puspa Dewi Narrij Lotulung
author_sort Teni Ernawati
title Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction
title_short Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction
title_full Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction
title_fullStr Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction
title_full_unstemmed Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction
title_sort structure modification of quinine on c-9 hydroxyl group via esterification reaction
publisher University of Brawijaya
series Journal of Pure and Applied Chemistry Research
issn 2302-4690
2302-4690
publishDate 2020-04-01
description Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development. A simple and efficient method for C-9 alkylation and arylation of quinine derivatives was reported. Series quinine derivatives were synthesized through the esterification of the hydroxyl group of quinine. The reaction with various alkyl and aryl carbonyl chloride resulted in the series of ester quinine derivatives. The structure of quinine derivatives was characterized by IR, melting point, UV, 1H NMR, 13C NMR, LCMS.
topic modification
synthesis
quinine derivatives
ester
url https://jpacr.ub.ac.id/index.php/jpacr/article/view/505/pdf
work_keys_str_mv AT teniernawati structuremodificationofquinineonc9hydroxylgroupviaesterificationreaction
AT minartiminarti structuremodificationofquinineonc9hydroxylgroupviaesterificationreaction
AT puspadewinarrijlotulung structuremodificationofquinineonc9hydroxylgroupviaesterificationreaction
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