Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction
Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development. A simple and efficient method for C-9 alkylation and arylation of quinine derivatives was reported. Series quinine derivatives...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
University of Brawijaya
2020-04-01
|
Series: | Journal of Pure and Applied Chemistry Research |
Subjects: | |
Online Access: | https://jpacr.ub.ac.id/index.php/jpacr/article/view/505/pdf |
id |
doaj-fc54e426ed7346be810d49cb7090b0e5 |
---|---|
record_format |
Article |
spelling |
doaj-fc54e426ed7346be810d49cb7090b0e52021-04-15T16:01:31ZengUniversity of BrawijayaJournal of Pure and Applied Chemistry Research2302-46902302-46902020-04-01913239Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification ReactionTeni Ernawati 0Minarti Minarti1Puspa Dewi Narrij Lotulung2Medicinal Chemistry Research Group Research Center for Chemistry (RCC) Indonesian Institute of Sciences (LIPI)Medicinal Chemistry Research Group Research Center for Chemistry (RCC) Indonesian Institute of Sciences (LIPI)Medicinal Chemistry Research Group Research Center for Chemistry (RCC) Indonesian Institute of Sciences (LIPI)Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development. A simple and efficient method for C-9 alkylation and arylation of quinine derivatives was reported. Series quinine derivatives were synthesized through the esterification of the hydroxyl group of quinine. The reaction with various alkyl and aryl carbonyl chloride resulted in the series of ester quinine derivatives. The structure of quinine derivatives was characterized by IR, melting point, UV, 1H NMR, 13C NMR, LCMS.https://jpacr.ub.ac.id/index.php/jpacr/article/view/505/pdfmodificationsynthesisquinine derivativesester |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Teni Ernawati Minarti Minarti Puspa Dewi Narrij Lotulung |
spellingShingle |
Teni Ernawati Minarti Minarti Puspa Dewi Narrij Lotulung Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction Journal of Pure and Applied Chemistry Research modification synthesis quinine derivatives ester |
author_facet |
Teni Ernawati Minarti Minarti Puspa Dewi Narrij Lotulung |
author_sort |
Teni Ernawati |
title |
Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction |
title_short |
Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction |
title_full |
Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction |
title_fullStr |
Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction |
title_full_unstemmed |
Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction |
title_sort |
structure modification of quinine on c-9 hydroxyl group via esterification reaction |
publisher |
University of Brawijaya |
series |
Journal of Pure and Applied Chemistry Research |
issn |
2302-4690 2302-4690 |
publishDate |
2020-04-01 |
description |
Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development. A simple and efficient method for C-9 alkylation and arylation of quinine derivatives was reported. Series quinine derivatives were synthesized through the esterification of the hydroxyl group of quinine. The reaction with various alkyl and aryl carbonyl chloride resulted in the series of ester quinine derivatives. The structure of quinine derivatives was characterized by IR, melting point, UV, 1H NMR, 13C NMR, LCMS. |
topic |
modification synthesis quinine derivatives ester |
url |
https://jpacr.ub.ac.id/index.php/jpacr/article/view/505/pdf |
work_keys_str_mv |
AT teniernawati structuremodificationofquinineonc9hydroxylgroupviaesterificationreaction AT minartiminarti structuremodificationofquinineonc9hydroxylgroupviaesterificationreaction AT puspadewinarrijlotulung structuremodificationofquinineonc9hydroxylgroupviaesterificationreaction |
_version_ |
1721526239770968064 |