Neuregulin-1β Partially Improves Cardiac Function in Volume-Overload Heart Failure Through Regulation of Abnormal Calcium Handling

Neuregulin-1β Partially Improves Cardiac Function in Volume-Overload Heart Failure Through Regulation of Abnormal Calcium Handling

Background: Neuregulin (NRG-1), an essential stress-mediated paracrine growth factor, has a cardioprotective effect in failing heart. However, the underlying mechanism remains unclear. The role of NRG-1β in heart failure (HF) rats was examined.Methods and Results: Volume-overload HF rat model was cr...

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Bibliographic Details
Main Authors: Xuehui Wang, Xiaozhen Zhuo, Jie Gao, Huibing Liu, Fei Lin, Aiqun Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
heart failure
neuregulin-1β
L-type calcium channel
calcium handling
SERCA2a
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00616/full

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