Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance
Abstract Background Atrial fibrillation (AF) is the most common arrhythmia in dogs. The Irish Wolfhound breed has a high prevalence of AF making them an ideal breed to investigate possible genetic contributions to this disease. The aim of this study was to perform a heritability analysis in North Am...
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doaj-fc7063221d954b57853ac47bc94dc1232020-12-13T12:37:45ZengBMCCanine Genetics and Epidemiology2052-66872019-12-01611510.1186/s40575-019-0079-yPedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritanceSamantha L. Fousse0William D. Tyrrell1Mariellen E. Dentino2Frances L. Abrams3Steven L. Rosenthal4Joshua A. Stern5Department of Medicine and Epidemiology, University of California Davis - School of Veterinary MedicineCVCA: Cardiac Care for PetsIrish Wolfhound FoundationIrish Wolfhound FoundationCVCA: Cardiac Care for PetsDepartment of Medicine and Epidemiology, University of California Davis - School of Veterinary MedicineAbstract Background Atrial fibrillation (AF) is the most common arrhythmia in dogs. The Irish Wolfhound breed has a high prevalence of AF making them an ideal breed to investigate possible genetic contributions to this disease. The aim of this study was to perform a heritability analysis in North American Irish Wolfhounds using phenotype data from cardiac screenings performed between 2000 and 2019 in order to determine how much of this disease can be attributed to genetics compared to environmental causes. The second aim was to determine the disease mode of inheritance to help inform prevention and breeding practices. Results There were 327 Irish Wolfhounds diagnosed with AF and 136 Irish Wolfhounds over 8 years of age without AF. The estimated mean (95% confidence interval) heritability of AF in Irish Wolfhounds was 0.69 (0.50–0.86). The pedigree was consistent with a dominant mode of inheritance. Conclusion Results of this study indicate a strong genetic contribution to AF in Irish Wolfhounds and suggest that future research to identify causative genetic mutations is warranted.https://doi.org/10.1186/s40575-019-0079-yVeterinaryGeneticsArrhythmiaBreedingDogCanine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Samantha L. Fousse William D. Tyrrell Mariellen E. Dentino Frances L. Abrams Steven L. Rosenthal Joshua A. Stern |
spellingShingle |
Samantha L. Fousse William D. Tyrrell Mariellen E. Dentino Frances L. Abrams Steven L. Rosenthal Joshua A. Stern Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance Canine Genetics and Epidemiology Veterinary Genetics Arrhythmia Breeding Dog Canine |
author_facet |
Samantha L. Fousse William D. Tyrrell Mariellen E. Dentino Frances L. Abrams Steven L. Rosenthal Joshua A. Stern |
author_sort |
Samantha L. Fousse |
title |
Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance |
title_short |
Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance |
title_full |
Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance |
title_fullStr |
Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance |
title_full_unstemmed |
Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance |
title_sort |
pedigree analysis of atrial fibrillation in irish wolfhounds supports a high heritability with a dominant mode of inheritance |
publisher |
BMC |
series |
Canine Genetics and Epidemiology |
issn |
2052-6687 |
publishDate |
2019-12-01 |
description |
Abstract Background Atrial fibrillation (AF) is the most common arrhythmia in dogs. The Irish Wolfhound breed has a high prevalence of AF making them an ideal breed to investigate possible genetic contributions to this disease. The aim of this study was to perform a heritability analysis in North American Irish Wolfhounds using phenotype data from cardiac screenings performed between 2000 and 2019 in order to determine how much of this disease can be attributed to genetics compared to environmental causes. The second aim was to determine the disease mode of inheritance to help inform prevention and breeding practices. Results There were 327 Irish Wolfhounds diagnosed with AF and 136 Irish Wolfhounds over 8 years of age without AF. The estimated mean (95% confidence interval) heritability of AF in Irish Wolfhounds was 0.69 (0.50–0.86). The pedigree was consistent with a dominant mode of inheritance. Conclusion Results of this study indicate a strong genetic contribution to AF in Irish Wolfhounds and suggest that future research to identify causative genetic mutations is warranted. |
topic |
Veterinary Genetics Arrhythmia Breeding Dog Canine |
url |
https://doi.org/10.1186/s40575-019-0079-y |
work_keys_str_mv |
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