Recovery from cortical blindness with mepivacaïne

Recovery from cortical blindness with mepivacaïne

Abstract We report the case of a patient suffering from cortical blindness following bilateral occipital stroke, who recovered normal vision in his right visual field following injection of the local anesthetic mepivacaïne. The effect was transient but reproducible, allowing the patient to lead a no...

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Main Authors: Laurent Cohen, Amélie Ponchel, Aurélie Kas, Sébastian Ströer, Antoine Del Cul, Guillaume Guérineau de Lamérie, Randa El Hachem, Piirika Crépin, Alexandre Morin
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.50832
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spelling doaj-fc7b11412b9b42578a008502abb239472021-05-02T11:40:33ZengWileyAnnals of Clinical and Translational Neurology2328-95032019-08-01681541154510.1002/acn3.50832Recovery from cortical blindness with mepivacaïneLaurent Cohen0Amélie Ponchel1Aurélie Kas2Sébastian Ströer3Antoine Del Cul4Guillaume Guérineau de Lamérie5Randa El Hachem6Piirika Crépin7Alexandre Morin8Institut du Cerveau et de la Moelle épinière, ICM Sorbonne Université Inserm U 1127, CNRS UMR 7225 F‐75013 Paris FranceInstitut du Cerveau et de la Moelle épinière, ICM Sorbonne Université Inserm U 1127, CNRS UMR 7225 F‐75013 Paris FranceService de médecine nucléaire Hôpital de la Pitié Salpêtrière, AP‐HP F‐75013 Paris FranceService de neuroradiologie Hôpital de la Pitié Salpêtrière, AP‐HP F‐75013 Paris FranceService de psychiatrie Hôpital de la Pitié Salpêtrière, AP‐HP F‐75013 Paris FranceDépartement d'information médicale Centre hospitalier Guillaume Régnier 35703 Rennes FranceService d’anesthésie Centre Hospitalier 11100 Narbonne FranceCentre Medico Psycho Pédagogique 11100 Narbonne FranceDépartement de neurologie Hôpital de la Pitié Salpêtrière, AP‐HP F‐75013 Paris FranceAbstract We report the case of a patient suffering from cortical blindness following bilateral occipital stroke, who recovered normal vision in his right visual field following injection of the local anesthetic mepivacaïne. The effect was transient but reproducible, allowing the patient to lead a normal life. Effect duration increased after adjunction of paroxetine. We provide anatomical and functional brain imaging correlates of this improvement, showing particularly how functional connectivity is restored between intact perilesional cortex and distant brain regions. This serendipitous finding may potentially benefit patients suffering from visual but also nonvisual handicap following brain lesions.https://doi.org/10.1002/acn3.50832
collection DOAJ
language English
format Article
sources DOAJ
author Laurent Cohen
Amélie Ponchel
Aurélie Kas
Sébastian Ströer
Antoine Del Cul
Guillaume Guérineau de Lamérie
Randa El Hachem
Piirika Crépin
Alexandre Morin
spellingShingle Laurent Cohen
Amélie Ponchel
Aurélie Kas
Sébastian Ströer
Antoine Del Cul
Guillaume Guérineau de Lamérie
Randa El Hachem
Piirika Crépin
Alexandre Morin
Recovery from cortical blindness with mepivacaïne
Annals of Clinical and Translational Neurology
author_facet Laurent Cohen
Amélie Ponchel
Aurélie Kas
Sébastian Ströer
Antoine Del Cul
Guillaume Guérineau de Lamérie
Randa El Hachem
Piirika Crépin
Alexandre Morin
author_sort Laurent Cohen
title Recovery from cortical blindness with mepivacaïne
title_short Recovery from cortical blindness with mepivacaïne
title_full Recovery from cortical blindness with mepivacaïne
title_fullStr Recovery from cortical blindness with mepivacaïne
title_full_unstemmed Recovery from cortical blindness with mepivacaïne
title_sort recovery from cortical blindness with mepivacaïne
publisher Wiley
series Annals of Clinical and Translational Neurology
issn 2328-9503
publishDate 2019-08-01
description Abstract We report the case of a patient suffering from cortical blindness following bilateral occipital stroke, who recovered normal vision in his right visual field following injection of the local anesthetic mepivacaïne. The effect was transient but reproducible, allowing the patient to lead a normal life. Effect duration increased after adjunction of paroxetine. We provide anatomical and functional brain imaging correlates of this improvement, showing particularly how functional connectivity is restored between intact perilesional cortex and distant brain regions. This serendipitous finding may potentially benefit patients suffering from visual but also nonvisual handicap following brain lesions.
url https://doi.org/10.1002/acn3.50832
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AT guillaumeguerineaudelamerie recoveryfromcorticalblindnesswithmepivacaine
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