Demyelination-Like Syndrome In Crohn’s Disease After Infliximab Therapy

Demyelination-Like Syndrome In Crohn’s Disease After Infliximab Therapy

An 18-year-old female patient with Crohn's disease involving the ileum and colon developed ankylosing spondylitis. After treatment of her spondylitis with multiple infliximab infusions, new onset of neurological symptoms developed, accompanied by detection of an abnormal white matter signal cha...

Full description

Bibliographic Details
Main Authors: Hugh J Freeman, Borys Flak
Format: Article
Language:English
Published: Hindawi Limited 2005-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2005/358658
id doaj-fc7b1766d6344893b08a528f39ce242c
record_format Article
spelling doaj-fc7b1766d6344893b08a528f39ce242c2020-11-24T21:17:44ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79002005-01-0119531331610.1155/2005/358658Demyelination-Like Syndrome In Crohn’s Disease After Infliximab TherapyHugh J Freeman0Borys Flak1Department of Medicine (Gastroenterology) and Department of Diagnostic Radiology, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Medicine (Gastroenterology) and Department of Diagnostic Radiology, University of British Columbia, Vancouver, British Columbia, CanadaAn 18-year-old female patient with Crohn's disease involving the ileum and colon developed ankylosing spondylitis. After treatment of her spondylitis with multiple infliximab infusions, new onset of neurological symptoms developed, accompanied by detection of an abnormal white matter signal change on magnetic resonance imaging examination. Although infliximab treatment was terminated, the neurological symptoms and the magnetic resonance imaging changes persisted. Development of new neuropsychiatric changes in Crohn's disease should be thoroughly evaluated to exclude a concomitant demyelinating process. Infliximab infusions should be terminated if demyelination is suspected.http://dx.doi.org/10.1155/2005/358658
collection DOAJ
language English
format Article
sources DOAJ
author Hugh J Freeman
Borys Flak
spellingShingle Hugh J Freeman
Borys Flak
Demyelination-Like Syndrome In Crohn’s Disease After Infliximab Therapy
Canadian Journal of Gastroenterology
author_facet Hugh J Freeman
Borys Flak
author_sort Hugh J Freeman
title Demyelination-Like Syndrome In Crohn’s Disease After Infliximab Therapy
title_short Demyelination-Like Syndrome In Crohn’s Disease After Infliximab Therapy
title_full Demyelination-Like Syndrome In Crohn’s Disease After Infliximab Therapy
title_fullStr Demyelination-Like Syndrome In Crohn’s Disease After Infliximab Therapy
title_full_unstemmed Demyelination-Like Syndrome In Crohn’s Disease After Infliximab Therapy
title_sort demyelination-like syndrome in crohn’s disease after infliximab therapy
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 2005-01-01
description An 18-year-old female patient with Crohn's disease involving the ileum and colon developed ankylosing spondylitis. After treatment of her spondylitis with multiple infliximab infusions, new onset of neurological symptoms developed, accompanied by detection of an abnormal white matter signal change on magnetic resonance imaging examination. Although infliximab treatment was terminated, the neurological symptoms and the magnetic resonance imaging changes persisted. Development of new neuropsychiatric changes in Crohn's disease should be thoroughly evaluated to exclude a concomitant demyelinating process. Infliximab infusions should be terminated if demyelination is suspected.
url http://dx.doi.org/10.1155/2005/358658
work_keys_str_mv AT hughjfreeman demyelinationlikesyndromeincrohnsdiseaseafterinfliximabtherapy
AT borysflak demyelinationlikesyndromeincrohnsdiseaseafterinfliximabtherapy
_version_ 1726012452398694400

Similar Items