Neuropharmacological potential of various morphological parts of Camellia sinensis L.

• Main Authors: Saima Rubab, Ghazala H. Rizwani, Saraj Bahadur, Muzammil Shah, Hameed Alsamadany, Yahya Alzahrani, Sameera A. Alghamdi, Yasir Anwar, Muhammad Shuaib, Asad Ali Shah, Ikram Muhammad, Wajid Zaman
• Format: Article
• Language: English
• Published: Elsevier 2020-01-01
• Series: Saudi Journal of Biological Sciences
• Online Access: http://www.sciencedirect.com/science/article/pii/S1319562X19302591

Camellia sinensis L. has long been used as a therapeutic agent for the Central nervous system (CNS) due to the presence of flavonoids. The present study aimed to evaluate the dose-dependent Neuropharmacological behavioral potential of Camellia sinensis seed and leaf extracts on mice. To evaluate the differential potential of leaf and seed extract various doses were prepared and examined in open field, head dip, rearing, cage cross, swimming and traction tests. One-way ANOVA set at P* < 0.05 followed by POST HOC LSD (P* < 0.01) was applied to evaluate the significant difference among the treatments. Herein both seed and leaf extract showed significant results at high doses. Interestingly leaf extract at high dose showed significant effect on mice CNS in open field and head dip test, while seed at high dose revealed significant stimulus on mice CNS in rearing, cage cross, swimming and traction tests. Overall results showed that seed produced more stimulant effect and less calmness as compared to leaf extract was. Tea leaves had already known as potential CNS stimulant drugs; current investigation suggests that tea seed can be used as an alternative CNS stimulant agent with more effective stimulant action. Keywords: Camellia sinensis, Therapeutic, Central nervous system, Pharmacological, Stimulant