Wheel-running activity modulates circadian organization and the daily rhythm of eating behavior
Consumption of high-fat diet acutely alters the daily rhythm of eating behavior and circadian organization (the phase relationship between oscillators in central and peripheral tissues) in mice. Voluntary wheel-running activity counteracts the obesogenic effects of high-fat diet and also modulates c...
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyg.2014.00177/full |
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doaj-fc827229680643bdad136679953b268c2020-11-25T02:41:13ZengFrontiers Media S.A.Frontiers in Psychology1664-10782014-03-01510.3389/fpsyg.2014.0017778341Wheel-running activity modulates circadian organization and the daily rhythm of eating behaviorJulie Suzanne Pendergast0Julie Suzanne Pendergast1Katrina L Branecky2Roya eHuang3Kevin D Niswender4Kevin D Niswender5Shin eYamazaki6Vanderbilt UniversityVanderbilt University Medical CenterVanderbilt UniversityGunn High SchoolVA Tennessee Valley Healthcare SystemVanderbilt University Medical CenterVanderbilt UniversityConsumption of high-fat diet acutely alters the daily rhythm of eating behavior and circadian organization (the phase relationship between oscillators in central and peripheral tissues) in mice. Voluntary wheel-running activity counteracts the obesogenic effects of high-fat diet and also modulates circadian rhythms in mice. In this study, we sought to determine whether voluntary wheel-running activity could prevent the proximate effects of high-fat diet consumption on circadian organization and behavioral rhythms in mice. Mice were housed with locked or freely rotating running wheels and fed chow or high-fat diet for one week and rhythms of locomotor activity, eating behavior, and molecular timekeeping (PERIOD2::LUCIFERASE luminescence rhythms) in ex vivo tissues were measured. Wheel-running activity delayed the phase of the liver rhythm by 4 hours in both chow- and high-fat diet-fed mice. The delayed liver phase was specific to wheel-running activity since an enriched environment without the running wheel did not alter the phase of the liver rhythm. In addition, wheel-running activity modulated the effect of high-fat diet consumption on the daily rhythm of eating behavior. While high-fat diet consumption caused eating events to be more evenly dispersed across the 24h-day in both locked-wheel and wheel-running mice, the effect of high-fat diet was much less pronounced in wheel-running mice. Together these data demonstrate that wheel-running activity is a salient factor that modulates liver phase and eating behavior rhythms in both chow- and high-fat-diet fed mice. Wheel-running activity in mice is both a source of exercise and a self-motivating, rewarding behavior. Understanding the putative reward-related mechanisms whereby wheel-running activity alters circadian rhythms could have implications for human obesity since palatable food and exercise may modulate similar reward circuits.http://journal.frontiersin.org/Journal/10.3389/fpsyg.2014.00177/fullLiverMetabolismMiceObesitycircadianC57BL/6J |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julie Suzanne Pendergast Julie Suzanne Pendergast Katrina L Branecky Roya eHuang Kevin D Niswender Kevin D Niswender Shin eYamazaki |
spellingShingle |
Julie Suzanne Pendergast Julie Suzanne Pendergast Katrina L Branecky Roya eHuang Kevin D Niswender Kevin D Niswender Shin eYamazaki Wheel-running activity modulates circadian organization and the daily rhythm of eating behavior Frontiers in Psychology Liver Metabolism Mice Obesity circadian C57BL/6J |
author_facet |
Julie Suzanne Pendergast Julie Suzanne Pendergast Katrina L Branecky Roya eHuang Kevin D Niswender Kevin D Niswender Shin eYamazaki |
author_sort |
Julie Suzanne Pendergast |
title |
Wheel-running activity modulates circadian organization and the daily rhythm of eating behavior |
title_short |
Wheel-running activity modulates circadian organization and the daily rhythm of eating behavior |
title_full |
Wheel-running activity modulates circadian organization and the daily rhythm of eating behavior |
title_fullStr |
Wheel-running activity modulates circadian organization and the daily rhythm of eating behavior |
title_full_unstemmed |
Wheel-running activity modulates circadian organization and the daily rhythm of eating behavior |
title_sort |
wheel-running activity modulates circadian organization and the daily rhythm of eating behavior |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychology |
issn |
1664-1078 |
publishDate |
2014-03-01 |
description |
Consumption of high-fat diet acutely alters the daily rhythm of eating behavior and circadian organization (the phase relationship between oscillators in central and peripheral tissues) in mice. Voluntary wheel-running activity counteracts the obesogenic effects of high-fat diet and also modulates circadian rhythms in mice. In this study, we sought to determine whether voluntary wheel-running activity could prevent the proximate effects of high-fat diet consumption on circadian organization and behavioral rhythms in mice. Mice were housed with locked or freely rotating running wheels and fed chow or high-fat diet for one week and rhythms of locomotor activity, eating behavior, and molecular timekeeping (PERIOD2::LUCIFERASE luminescence rhythms) in ex vivo tissues were measured. Wheel-running activity delayed the phase of the liver rhythm by 4 hours in both chow- and high-fat diet-fed mice. The delayed liver phase was specific to wheel-running activity since an enriched environment without the running wheel did not alter the phase of the liver rhythm. In addition, wheel-running activity modulated the effect of high-fat diet consumption on the daily rhythm of eating behavior. While high-fat diet consumption caused eating events to be more evenly dispersed across the 24h-day in both locked-wheel and wheel-running mice, the effect of high-fat diet was much less pronounced in wheel-running mice. Together these data demonstrate that wheel-running activity is a salient factor that modulates liver phase and eating behavior rhythms in both chow- and high-fat-diet fed mice. Wheel-running activity in mice is both a source of exercise and a self-motivating, rewarding behavior. Understanding the putative reward-related mechanisms whereby wheel-running activity alters circadian rhythms could have implications for human obesity since palatable food and exercise may modulate similar reward circuits. |
topic |
Liver Metabolism Mice Obesity circadian C57BL/6J |
url |
http://journal.frontiersin.org/Journal/10.3389/fpsyg.2014.00177/full |
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