Laryngeal Involvement of Multiple Myeloma
The objectives of this paper are to discuss a rare cause of laryngeal multiple myeloma, to review unique pathologic findings associated with plasma cell neoplasms, to discuss epidemiology, differential diagnosis, and treatment options for plasma cell neoplasms of the larynx. Laryngeal multiple myelo...
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2012-01-01
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Series: | Case Reports in Oncological Medicine |
Online Access: | http://dx.doi.org/10.1155/2012/257814 |
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doaj-fc8cbb0371ab465eaf7d1f79066a05f12020-11-24T22:09:19ZengHindawi LimitedCase Reports in Oncological Medicine2090-67062090-67142012-01-01201210.1155/2012/257814257814Laryngeal Involvement of Multiple MyelomaAriel B. Grobman0Richard J. Vivero1German Campuzano-Zuluaga2Parvin Ganjei-Azar3David E. Rosow4Department of Otolaryngology, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Suite 572, Miami, FL 33136, USADepartment of Otolaryngology, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Suite 572, Miami, FL 33136, USADepartment of Pathology, Miller School of Medicine, University of Miami, 1120 NW 14th Street, 14th Floor, Miami, FL 33136, USADepartment of Pathology, Miller School of Medicine, University of Miami, 1120 NW 14th Street, 14th Floor, Miami, FL 33136, USADepartment of Otolaryngology, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Suite 572, Miami, FL 33136, USAThe objectives of this paper are to discuss a rare cause of laryngeal multiple myeloma, to review unique pathologic findings associated with plasma cell neoplasms, to discuss epidemiology, differential diagnosis, and treatment options for plasma cell neoplasms of the larynx. Laryngeal multiple myeloma, also noted in the literature as “metastatic” multiple myeloma, presenting as a de novo laryngeal mass is extremely rare with few reported cases. Laryngeal involvement of extramedullary tumors is reported to be between 6% and 18% with the epiglottis, glottis, false vocal folds, aryepiglottic folds, and subglottis involved in decreasing the order of frequency. We present the case of a 58-year-old male with a history of IgA smoldering myeloma who presented to a tertiary care laryngological practice with a two-month history of dysphonia, which was found to be laryngeal involvement of multiple myeloma. We review the classification of and differentiation between different plasma cell neoplasms, disease workups, pathologic findings, and treatment options.http://dx.doi.org/10.1155/2012/257814 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ariel B. Grobman Richard J. Vivero German Campuzano-Zuluaga Parvin Ganjei-Azar David E. Rosow |
spellingShingle |
Ariel B. Grobman Richard J. Vivero German Campuzano-Zuluaga Parvin Ganjei-Azar David E. Rosow Laryngeal Involvement of Multiple Myeloma Case Reports in Oncological Medicine |
author_facet |
Ariel B. Grobman Richard J. Vivero German Campuzano-Zuluaga Parvin Ganjei-Azar David E. Rosow |
author_sort |
Ariel B. Grobman |
title |
Laryngeal Involvement of Multiple Myeloma |
title_short |
Laryngeal Involvement of Multiple Myeloma |
title_full |
Laryngeal Involvement of Multiple Myeloma |
title_fullStr |
Laryngeal Involvement of Multiple Myeloma |
title_full_unstemmed |
Laryngeal Involvement of Multiple Myeloma |
title_sort |
laryngeal involvement of multiple myeloma |
publisher |
Hindawi Limited |
series |
Case Reports in Oncological Medicine |
issn |
2090-6706 2090-6714 |
publishDate |
2012-01-01 |
description |
The objectives of this paper are to discuss a rare cause of laryngeal multiple myeloma, to review unique pathologic findings associated with plasma cell neoplasms, to discuss epidemiology, differential diagnosis, and treatment options for plasma cell neoplasms of the larynx. Laryngeal multiple myeloma, also noted in the literature as “metastatic” multiple myeloma, presenting as a de novo laryngeal mass is extremely rare with few reported cases. Laryngeal involvement of extramedullary tumors is reported to be between 6% and 18% with the epiglottis, glottis, false vocal folds, aryepiglottic folds, and subglottis involved in decreasing the order of frequency. We present the case of a 58-year-old male with a history of IgA smoldering myeloma who presented to a tertiary care laryngological practice with a two-month history of dysphonia, which was found to be laryngeal involvement of multiple myeloma. We review the classification of and differentiation between different plasma cell neoplasms, disease workups, pathologic findings, and treatment options. |
url |
http://dx.doi.org/10.1155/2012/257814 |
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