Molecular Mechanism of Thymidylate Synthase Inhibition by N<sup>4</sup>-Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies

Molecular Mechanism of Thymidylate Synthase Inhibition by N<sup>4</sup>-Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies

Novel evidence is presented allowing further clarification of the mechanism of the slow-binding thymidylate synthase (TS) inhibition by N<sup>4</sup>-hydroxy-dCMP (N<sup>4</sup>-OH-dCMP). Spectrophotometric monitoring documented time- and temperature-, and N<sup>4</s...

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Bibliographic Details
Main Authors: Piotr Maj, Adam Jarmuła, Piotr Wilk, Małgorzata Prokopowicz, Wojciech Rypniewski, Zbigniew Zieliński, Anna Dowierciał, Agnieszka Bzowska, Wojciech Rode
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
thymidylate synthase
dihydrofolate production
N<sup>4</sup>-hydroxy-dCMP binding
imidazolidine ring opening
Online Access:https://www.mdpi.com/1422-0067/22/9/4758

Internet

https://www.mdpi.com/1422-0067/22/9/4758

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