Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role?
Despite significant progress in trisomy 21 (T21) diagnostic tools, amniocentesis is still used for the confirmation of an abnormal fetal karyotype. Invasive tests carry the potential risk of miscarriage; thus, screening biomarkers are commonly used before undergoing invasive procedures. In our study...
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doaj-fcab71c106294cc8befc6ae2944e99ca2021-06-01T01:28:28ZengMDPI AGJournal of Clinical Medicine2077-03832021-05-01102382238210.3390/jcm10112382Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role?Angelika Buczyńska0Iwona Sidorkiewicz1Sławomir Ławicki2Adam Jacek Krętowski3Monika Zbucka-Krętowska4Clinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, PolandClinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, PolandDepartment of Population Medicine and Civilization Diseases Prevention, Medical University of Bialystok, 15-276 Bialystok, PolandClinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, PolandDepartment of Gynecological Endocrinology and Adolescent Gynecology, Medical University of Bialystok, 15-276 Bialystok, PolandDespite significant progress in trisomy 21 (T21) diagnostic tools, amniocentesis is still used for the confirmation of an abnormal fetal karyotype. Invasive tests carry the potential risk of miscarriage; thus, screening biomarkers are commonly used before undergoing invasive procedures. In our study, we investigated the possible application of oxidative stress markers in the prenatal screening of trisomy 21. The DNA/RNA oxidative stress damage products (OSDPs), advanced glycation end (AGE) products, ischemia-modified albumin (IMA), alfa-1-antitrypsin (A1AT), asprosin, and vitamin D concentrations were measured in both maternal plasma and amniotic fluid in trisomy 21 (T21) and euploid pregnancies. The obtained results indicated increased levels of DNA/RNA OSDPs and asprosin with simultaneous decreased levels of vitamin D and A1AT in the study group. The diagnostic utility of the plasma measurement based on the area under the received operative characteristic (ROC) curve (AUC) calculation of asprosin (AUC = 0.965), IMA (AUC = 0.880), AGE (AUC = 0.846) and DNA/RNA OSDPs (AUC = 0.506) in T21 screening was demonstrated. The obtained results indicate a potential role for the application of oxidative stress markers in the prenatal screening of T21 with the highest screening utility of plasma asprosin.https://www.mdpi.com/2077-0383/10/11/2382trisomy 21Down syndromeoxidative stressantioxidant proteinprenatal screening |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Angelika Buczyńska Iwona Sidorkiewicz Sławomir Ławicki Adam Jacek Krętowski Monika Zbucka-Krętowska |
spellingShingle |
Angelika Buczyńska Iwona Sidorkiewicz Sławomir Ławicki Adam Jacek Krętowski Monika Zbucka-Krętowska Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role? Journal of Clinical Medicine trisomy 21 Down syndrome oxidative stress antioxidant protein prenatal screening |
author_facet |
Angelika Buczyńska Iwona Sidorkiewicz Sławomir Ławicki Adam Jacek Krętowski Monika Zbucka-Krętowska |
author_sort |
Angelika Buczyńska |
title |
Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role? |
title_short |
Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role? |
title_full |
Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role? |
title_fullStr |
Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role? |
title_full_unstemmed |
Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role? |
title_sort |
prenatal screening of trisomy 21: could oxidative stress markers play a role? |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-05-01 |
description |
Despite significant progress in trisomy 21 (T21) diagnostic tools, amniocentesis is still used for the confirmation of an abnormal fetal karyotype. Invasive tests carry the potential risk of miscarriage; thus, screening biomarkers are commonly used before undergoing invasive procedures. In our study, we investigated the possible application of oxidative stress markers in the prenatal screening of trisomy 21. The DNA/RNA oxidative stress damage products (OSDPs), advanced glycation end (AGE) products, ischemia-modified albumin (IMA), alfa-1-antitrypsin (A1AT), asprosin, and vitamin D concentrations were measured in both maternal plasma and amniotic fluid in trisomy 21 (T21) and euploid pregnancies. The obtained results indicated increased levels of DNA/RNA OSDPs and asprosin with simultaneous decreased levels of vitamin D and A1AT in the study group. The diagnostic utility of the plasma measurement based on the area under the received operative characteristic (ROC) curve (AUC) calculation of asprosin (AUC = 0.965), IMA (AUC = 0.880), AGE (AUC = 0.846) and DNA/RNA OSDPs (AUC = 0.506) in T21 screening was demonstrated. The obtained results indicate a potential role for the application of oxidative stress markers in the prenatal screening of T21 with the highest screening utility of plasma asprosin. |
topic |
trisomy 21 Down syndrome oxidative stress antioxidant protein prenatal screening |
url |
https://www.mdpi.com/2077-0383/10/11/2382 |
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